Mammalian innate-like T cells (ILTCs), including mucosal-associated invariant T (MAIT), natural killer T (NKT), and γδ T cells, are abundant tissue-resident lymphocytes that have recently emerged as orchestrators of hepatic inflammation, tissue repair, and immune homeostasis. This review explore...
In contrast, innate-like T cells quickly respond to pathogens and display effector functions without undergoing extensive clonal expansion. Specifically, the activation of innate-like T cells depends on the promiscuous interaction of highly conserved antigen-presenting molecules, non-peptidic antigens, ...
In a recent study published inNature, Chou and colleagues define a new evolutionarily conserved class of tumour-elicited immune response mediated by a distinct population of T cell receptor (TCR)-positive FCER1G-expressing innate-like T cells with high cytotoxic potential (αβILTCKs).1 Targeted ...
cells can straddle innate and adaptive immunity, we found that signaling via antigen receptors, whose conventional role is to facilitate clonal T cell activation, was critical for the development of innate-like T cells but then was rapidly attenuated, which accommodated the cells' innate ...
Here, in a survey of T cells in mouse and human malignancies, we identified a population of αβ T cell receptor (TCR)-positive FCER1G-expressing innate-like T cells with high cytotoxic potential8 (ILTCKs). These cells were broadly reactive to unmutated self-antigens, arose from distinct ...
1) regulation of these decisions in humoral immune responses (Rauschmeier et al,J Exp Med, 2022; Glaros et al,Immunity, 2021) and 2) specificity, development and function of innate-like lymphocytes, in particular –γδT cells (You et al,Nat Immunol, 2024; Dunst et al,JLB, 2020; Kre...
Inherent immune cells, mainly including phagocytes CD4, NK NKT stem cells, stem cells, cells, B T 1 Cell, mast cell alkaline tablets and bloodthirsty stem cells and stem cells international acid tablets. 翻译结果5复制译文编辑译文朗读译文返回顶部 ...
Intestinal intraepithelial T lymphocytes (IELs) are likely to play a key role in host mucosal immunity and, unlike other T cells, have been proposed to dif... G Eberl,RL Dan - 《Science》 被引量: 964发表: 2004年 Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues ...
aIn addition, many innate immune cells can act as antigen-presenting cells (APCs) and activate the adaptive immune response, with T and B lymphocytes being the central orchestrators of adaptive immunity. 此外,很多先天免疫细胞可能作为赠送抗原的 细胞 ( APCs ) 和激活适应免疫答复,利用 T 和 B 淋巴...
Here, we show that NK cells negatively regulate the duration and effectiveness of virus-specific CD4+ and CD8+ T cell responses by limiting exposure of T cells to infected antigen-presenting cells. This impacts the quality of T cell responses and the ability to limit viral persistence. Our ...