spinal motoneuronWe are studying the mechanisms of H‐reflex operant conditioning, a simple form of learning. Modelling studies in the literature and our previous data suggested that changes in the axon initial segment (AIS) might contribute. To explore this, we used blinded quantitative ...
AIS axon initial segment 1. Introduction A critical aspect of neuronal polarity occurs at the level of compartmentalizing a vast and diverse repertoire of proteins to either the axonal or somatodendritic domains. This compartmentalization, or polarization, organizes the neuron into biochemically, morpholog...
Figure 1. Overview of AIS assembly site analysis (A) The workflow of the AIS localization analysis for a neuron. The filtered β3-tubulin fluorescence image of the neuron is used to generate the 3D reconstruction, from which the first few lowest-order harmonics and their nodal plane positions...
The axon initial segment (AIS) is a region of the neuron that is critical for action potential generation as well as for the regulation of neural activity. This specialized structure—characterized by the expression of different types of ion channels as well as adhesion, scaffolding and cytoskeleto...
Objective: Inhibition mediated by γ-aminobutyric acid at the axon initial segment of pyramidal neurons appears to be altered in the prefrontal cortex in schizophrenia. This study examined the densities and laminar distribution of axon initial segments labeled with an antibody against the serotonin1A ...
The axon initial segment (AIS) plays a crucial role: it is the site where neurons initiate their electrical outputs. Its composition in terms of voltage-gated sodium (Nav) and voltage-gated potassium (Kv) channels, as well as its length and localization determine the neuron's spiking propertie...
Here we used lentiviral-mediated knockdown of the cell adhesion molecule neurofascin in the basolateral amygdala (BLA) to specifically remove inhibitory synapses at the axon initial segment (AIS) of BLA projection neurons. Quantitative analysis of GABAergic synapse markers and measurement of miniature ...
Neuron 83 1418–1430. 10.1016/j.neuron.2014.08.013 [ Cross Ref ]Kuba H. Structural tuning and plasticity of the axon initial segment in auditory neurons. J Physiol 2012; 590:5571-5579.H. Kuba, "Structural tuning and plasticity of the axon initial segment in auditory ne...
action potential, action-potential initiation, Na+ channel, patch-clamp recording, hippocampus, pyramidal neuron, single-channel recording, dual-electrode recordingA long-standing hypothesis is that action potentials initiate first in the axon hillock/initial segment (AH–IS) region because of a ...
Figure 1. Anatomy of the Axon Initial Segment (A) Schematic of a pyramidal neuron axon showing the location of the hillock, initial segment (AIS; red), and axon proper. Synaptic input onto the AIS is shown in blue. (B) Electron micrograph of the AIS of a cortical pyramidal neuron. The...