Loss of INI-1 gene leads to dismal prognosis in a subset of SNUCs and therefore, it is encouraged to perform INI-1 staining in all cases of SNUC to stratify and prognosticate patients Suggestions: Further large-scale studies are necessary to determine if ID-SNUC represents a unique clinical ...
EBV潜伏感染有时会引起各种致瘤性疾病，如EBV相关淋巴组织增生性疾病、伯基特淋巴瘤、霍奇金淋巴瘤、NK...
几乎所有低分化脊索瘤都是INI 1阴性,也就是说他们不表达INI 1蛋白。 3. Dedifferentiated chordoma is more aggressiveand generally grows faster than the other types ofchordoma, and is more likely to metastasize thanconventional chordoma. It can also have loss of theINI1 gene, but this is not commo...
Nuclear INI-1 expression is seen in virtually all normal human tissues and most malignancies but the INI-1 gene is often mutated or deleted in malignant rhabdoid tumors (MRT), including those arising in the central nervous system, leading to a lack of INI-1 expression.[1] 品質 IVD IVD ...
Rhabdoid tumours have been shown to carry somatic mutations in the INI1 (SMARCB1/hSNF5) gene. A considerable fraction of these tumours exhibit allelic losses on chromosome 22. Allelic loss on 22q also is characteristic for meningiomas, however most of these alterations are considered to be ...
In both cases, INI1 gene deletion was detected by FISH. ConclusionsPoorly-differentiated chordoma with INI1 loss mainly occurs in children. The morphology is different from classical chordoma.INI1 gene deletion is detectable by FISH. It can be distinguished from atypical teratoid/rhabdoid tumors and...
SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas[J]. Cancer Res, 2005,65(10):4012–4019. 返回引文位置Google Scholar 百度学术 万方数据 [29] Laskin WB , Miettinen M . Epithelioid sarcoma: new insights based on an extended immunohistochemical analysis[J]. Arch...
Gene Name SMARCB1 BAF47 INI1 SNF5L1 Protein Name INI-1 Human Gene ID 6598 Immunogen Synthesized peptide derived from human INI-1 Specificity This antibody detects endogenous levels of INI-1 Source Mouse Concentration 1 mg/ml Purification The antibody was affinity-purified from mouse asc...
INI1 gene was detected in 1 of the 6 cases.Deletion of INI1 gene including heterozygous deletion,homozygous deletion and haploid was observed in 8 of the 11 cases.Conclusions Owing to the histologic heterogeneity,pitfalls in diagnosis of ES sometimes are encountered.INI1 is lost in most cases ...
In situ hybridization (ISH) was used to detect EBER and fluorescence in situ hybridization (FISH) to detect INI1 gene deletion. ResultsThe 16 cases of SDSC accounted for 1.3% (16/1 218) of all malignant sinonasal tumors in the author′s unit during this time period, and 2.4% (16/657...