When vaccine strains are well-matched with circulating strains, vaccination provides healthy adults younger than 65 years with 70–90% protection [13], and reduced hospitalizations in the elderly and those with chronic illnesses by 30–70% [14,15,16]. However, in years when there is a ...
The greatest difficulty of the vaccine lies in the great variability of the influenza virus. The A and influenza viruses are the most important ones. The A viruses include several subtypes, H3N2 and H1N1 being presently the most important ones. The present vaccine, therefore, must be updated ...
52. Zost SJ, Parkhouse K, Gumina ME, Kim K, Diaz Perez S, Wilson PC, Treanor JJ, Sant AJ, Cobey S, Hensley SE. 2017. Contemporary H3N2 influenza viruses have a gly- cosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains. Proc Natl Acad Sci USA ...
Using a human tonsil organoid model, we tracked the differentiation and kinetics of the adaptive immune response to influenza vaccine and virus modalities. Each antigen format elicited distinct B and T cell responses, including differences in their magnitude, diversity, phenotype, function, and breadth...
We tested the hypothesis that immunization with a pandemic influenza virus vaccine boosts pre-existing anti-stalk antibodies. We used chimeric cH6/1, full length H2 and H18 HA antigens in an ELISA to measure anti-stalk antibodies in recipients participating in clinical trials of A/H1N1, A/...
to contract a strain of the virus that is different from those included in the seasonal vaccine. It is also possible to become infected with a strain that is included in the vaccine, although symptoms are usually less severe than they would be if the person had not received the vaccine. ...
Measles: Quick Facts About the Vaccine and How It Spreads Measles is a contagious virus that mainly affects babies and young children. Learn about how it spreads, dangerous complications, and the vaccine. “I don’t think we have to be in panic mode,” said Alexea Gaffney-Adams, MD, an ...
156,157 The vaccine is well tolerated and highly effective in children but is associated with an increased frequency of wheezing in children younger than 2 years of age. Live vaccine is protective in adults as well, resulting in decreased laboratory-confirmed influenza in challenge studies and ...
Provided are octavalent influenza vaccine compositions comprising eight mRNA, each mRNA comprising an open reading frame encoding a different influenza antigen. Also provided are li
Low dose: The term “low dose,” as used herein in reference to subunit vaccines, refers to a dosage amount of less than 100 μg of plant-produced antigen (e.g., influenza antigen polypeptide, fusion thereof, and/or immunogenic portion thereof) and/or vaccine composition comprising plant-pr...