A mixed strain capable of efficient human-to-human transmission may cause a serious pandemic with fatal mortality rates. A basic requirement for the development of new antiviral agents and vaccines against the influenza A virus is the understanding of how and why influenza viruses cause disease in...
Sankar GaneshRamakrishnan, ...MariadhasValan Arasu, inMicrobial Pathogenesis, 2021 2.1Influenza A viruses Influenza Aviruses is one among the six genera of the familyOrthomyxoviridaeand consists of negative single-stranded RNA as its genetic material. Influenza A virus is mainly associated with epidemi...
Influenza viruses Influenza is a single-stranded segmented negative-sense RNAgenome virusof the familyOrthomyxoviridae. There are three types of influenza viruses:influenza virus A,influenza virus B, and influenza virus C.Influenza Aand C infect multiple species, whileinfluenza Binfects humans ...
Influenza viruses constitute a significant threat to public health worldwide over many decades, and continue to inflict significant morbidity and mortality... T Narasaraju,C Fong,SK Lal,... 被引量: 0发表: 2023年 Impact of Secondary Organic Aerosol Exposure on the Pathogenesis of Human Influenza...
The influenza A virus protein PB1-F2 has been linked to the pathogenesis of both primary viral and secondary bacterial infections. H3N2 viruses have histor... IV Alymova,AM Green,NVD Velde,... - 《Journal of Virology》 被引量: 92发表: 2011年 Assessing the Viral Fitness of Oseltamivir-Res...
Influenza viruses are presumed, but not conclusively known, to spread among humans by several possible routes. We provide evidence of a mode of transmission seldom considered for influenza: airborne virus transport on microscopic particles called “aerosolized fomites.” In the guinea pig model of inf...
The interplay between influenza A viruses (IAV) and the p53 pathway has been reported in several studies, highlighting the antiviral contribution of p53. Here, we investigated the impact of IAV on the E3-ubiquitin ligase Mdm2, a major regulator of p53, and observed that IAV targets Mdm2, nota...
Pathogenesis of Avian Influenza A (H5N1) Viruses in Ferrets BALB/c mouse model, whereas A/Hong Kong/486/97 virus was isolated from a case with mild illness and exhibited a low-pathogenicity phenotype in mice... LA Zitzow,T Rowe,T Morken,... - 《Journal of Virology》 被引量: 2167发表...
In addition to capturing the public imagination, the 1918 virus reconstruction opened up new opportunities to characterize the pathogenesis and transmission properties of highly virulent human influenza viruses. It is with this as a background that the components of this volume were conceived. The ...
关键词:禽流感病毒;致病性;进化;变异;基因重组 中图分类号:R373.1 + 3文献标识码:ADOI:10.3969/j.issn.1671-3141.2013.11.005 TheAvianInfluenzaVirusPathogenicityBasisofGeneticProgram Halidan•Yunusijiang 1 ,Rexidan•Zhakere 2 ( theFriendshipHospitalofIliKazakPrefecture,Xinjiang,China,835000;2.thesixt...