1 It is characterized by an inflammatory polyarthropathy, but has multiple extra-articular manifestations, such as pericarditis, splenomegaly, ocular inflammation, and subcutaneous nodules, and is thought to have both a genetic and environmental basis. ...
Describes a study of inflammatory polyarthropathy using tax-transgenic mice that expresses vital Tax protein under the control of the mouse metallothionein (MT) promoter. Experimental procedure; Relation of disease development on tax copy number; Histopathologic characteristics of ankle joints; Tax ...
al., 1990;Toussirot et al., 1994). It is likely that multiple etiologic agents induce this abnormal inflammatory activity. Beyondgenetic factors, chronic viral infection including immunodeficiency virus must be considered (Mijiyawa, 1993). Of particular interest for nonhuman primate spondyloarthropathy...
Patients may also present with polyarthralgia or nonerosive arthritis affecting large joints; cervical lymphadenopathy; sore throat and oral ulcers; hepatosplenomegaly and abdominal manifestations such as pain, vomiting, and diarrhea; and variable skin lesions, including maculopapular, urticarial, nodular...
Around 40% patients may have extraintestinal complications; commonest being IBD-associated arthropathy (IBDAA) [11]. Though IBDAA in adults is classified as spondyloarthritis, it is not included in International League Against Rheumatism (ILAR) classification of JIA. Clinical features of this arthritis...
One important distinguishing feature is that RA patients often develop joint erosion with aggressive osteoclast formation/activity, whereas SLE arthropathy is usually non-erosive61,62. In addition, type-I IFN signature is common in SLE patients, and recent literature noted reduced serum TGFβ level ...
Autoimmune polyglandular syndrome type I (APS1). APSI is a very rare systemic autosomal recessive disorder caused by mutations in the autoimmune regulator (AIRE) gene (49) and is immunologically characterized by multiple auto- antibodies and clinically masquerading as Addison's disease, and/or hypo...
Gastroenterol Vol 14 No 3 March 2000 Individual A (Healthy) Susceptibility genes 123456789 B (Total UC) 123456789 C (Small bowel CD) 123456789 D (Large bowel CD) 123456789 E (IBD, Jewish) 123456789 F (IBD, arthropathy) 123456789 Figure 1) Genetic heterogeneity in inflammatory bowel disease (...
Horai R, Saijo S, Tanioka H, Nakae S, Sudo K, Okahara A, Ikuse T, Asano M, Iwakura Y (2000) Development of chronic inflam- matory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J Exp Med 191(2):313–320 64. Keffer J, Probert L, Caz...
Case report 2019 UC, Spondyloarthropathy 1 VDZ+TOFA The patient achieved clinical remission for both digestive and rheumatologic symptoms No adverse events were observed, especially no infections. 12wk Berre et al. [107] Case report 2019 UC, seronegative HLA B27 inflammatory spondyloarthritis 1 VDZ...