rheumatoid arthritisautoimmunitycytokineanimal modelInterleukin (IL)-1 is a proinflammatory cytokine that plays important roles in inflammation, host defense, and the neuro-immuno-endocrine network. IL-1 receptor antagonist (ra) is an endogenous inhibitor of IL-1 and is supposed to regulate IL-1 ...
Research on the influence of gut microbiota on systemic inflammatory arthritis has exploded in the past decade. Gut microbiota changes may be a crucial regulatory component in systemic inflammatory arthritis. As a result of advancements in the field, microbiota-assisted therapy has evolved, but this ...
Since the approval of infliximab [8], the first monoclonal antibody against TNF for rheumatoid arthritis (RA), TNF inhibitors including adalimumab, certolizumab, golimumab and the fusion protein etanercept are increasingly utilised as therapy for rheumatoid arthritis (RA), inflammatory bowel disease (...
Rheumatoid arthritis—This inflammatory disease of the synovium, or lining of the joint, results in pain, stiffness, swelling, joint damage and loss of function of the joints. Inflammation most often affects joints of the hands and feet and tends to be symmetrical (occurring equally on both side...
In contrast, rheumatoid arthritis (RA) and hemophilic arthropathy (HA) display marked destruction of bone tissues caused by synovitis. RA is a representative autoimmune disease. The primary tissue of RA pathogenesis is the synovial membrane and involves various immune cells that produce catabolic ...
1991. Induction of inflammatory arthropathy resembling rheumatoid arthri- tis in mice transgenic for HTLV-I. Science. 253:1026-1028. doi:10 .1126/science.1887217Iwakura, Y., M. Tosu, E. Yoshida, M. Takiguchi, K. Sato, I. Kitajima, K. Nishioka, K. Yamamoto, T. Takeda, M. Hatanaka, ...
The most common final diagnoses were undifferentiated arthritis (UA) (39.9%), rheumatoid arthritis (RA) (22.7%), reactive arthritis (17.1%), psoriatic arthritis (6.0%) and sarcoid arthropathy/Lfgren's syndrome (6.2%). A final diagnosis of sarcoid arthropathy, reactive arthritis and UA carried...
Twenty-three patients had IRD (rheumatoid arthritis in 9, gout in 6, systemic lupus erythematosus in 3, spondyloarthropathy in 2, and one patient each with dermatomyositis, overlap syndrome, and unclassified polyarthralgia). Clinical manifestations and laboratory findings were similar to IRD patients...
There is evolving research in many chronic inflammatory states, such as chronic liver disease and rheumatoid arthritis, whereby interventions have begun to be developed to counteract sarcopenia. The purpose of this review is to evaluate the current literature regarding the impact of sarcopenia in the ...
monitoring of patients treated with TNFis is necessary in order to detect paradoxical reactions. In this study we focus on reviewing IBD occurrence as a paradoxical effect of TNFi therapy in patients with rheumatological diseases (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ...