Compared with healthy control group mice, the spleen index of mice treated by DXM + GM enema at 2 weeks was reduced in response to radiation (Fig. 2B, ***P < 0.001). Therefore, long-term use of the DXM + GM enema may affect the role of the spleen in immunity. Figure...
Imaging inflammation holds immense potential for advancing the diagnosis, treatment and prognosis of many conditions1,2,3. The lack of a specific and sensitive positron emission tomography (PET) probe to detect inflammation is a critical challenge. To bridge this gap, we present CD45-PET imaging,...
Katherine A Burns et al. suggested that endometriosis is divided into two stages (immune-predominant phase and hormone-predominant phase). They have demonstrated that early stage (< 72 h) of endometriosis is predominantly dependent on the signaling of the innate immune system, whereas estradiol/e...
Inflammation is a defensive response of the organism to irritation which is manifested by redness, swelling, heat, pain and dysfunction. The inflammatory response underlies the role of various diseases. Ferroptosis, a unique modality of cell death, driven by iron-dependent lipid peroxidation, is regu...
We enumerated innate-like B cells in the peritoneal cavity (PerC) and MZ of the spleen in offspring of MIA- and saline-treated litters at P14 (Figures 7A–7C). Although conventional B2 cells were unchanged in response to MIA, both CD5+ B1-a cells and CD5− B1-b cells were ...
Despite advancements in medical technology, the challenges of diagnosing fever of unknown origin (FUO) and inflammation of unknown origin (IUO) persist. Positron emission tomography/computed tomography (PET/CT) has been used to assess these conditions; however, it is unclear which patients most benef...
This early microbial stimulus has short-term consequences on the host homeostasis. It switches the pup’s immune response to an inflammatory context and alters the epithelium structure and the mucus-producing cells, disrupting gut homeostasis. This presence of a too diverse microbiota in the very ...
Chronic ICM and the Spleen A recent article by Ismahil et al96 examined a role for the spleen during the chronic phase of ischemic HF, 8 weeks post MI. This represents a time at which the initial inflammatory response would have stabilized and chronic cardiac remodeling would be the driving...
The predominant site of expression of 35 K-Fc mRNA is the liver, as there was no detectable gene expression in the lung and barely detectable expression in the spleen (Fig. 2D). As we had previously produced a range of 35 K-Fc point-mutants including one with enhanced bioactivity...
(TLR)-mediated detection of viral nucleic acids (NAs) and production of type I interferon (IFN-I) are key elements of antiviral defense, while inappropriate recognition of self NAs with the induction of IFN-I responses is linked to autoimmunity such as psoriasis and systemic lupus erythematosus....