During the past decades, there has been strong epidemiological evidence showing that nonsteroidal anti-inflammatory drugs (NSAIDs), especially aspirin, have been associated with a reduction in the incidence and
(TLR)-mediated detection of viral nucleic acids (NAs) and production of type I interferon (IFN-I) are key elements of antiviral defense, while inappropriate recognition of self NAs with the induction of IFN-I responses is linked to autoimmunity such as psoriasis and systemic lupus erythematosus....
During the past decades, there has been strong epidemiological evidence showing that nonsteroidal anti-inflammatory drugs (NSAIDs), especially aspirin, have been associated with a reduction in the incidence and mortality of a variety of types of cancer with long-term use, especially colorectal cancer...
Notch–RBP-J signaling controls the homeostasis of CD8− dendritic cells in the spleen. J. Exp. Med. 204, 1653–1664 (2007). CAS PubMed PubMed Central Google Scholar Inagaki, K. et al. SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility. EMBO J. 19, 6721...
the cofactor of DNA Polymerase, cell cycle phase transitioning (G1/S),9 and other macromolecule metabolisms.10,11 Extra- metabolic iron is stored in the form of ferritin and hemosi derin in the reticuloendothelial system mainly in the liver and macrophage of the spleen.12 In order to ...
Chronic inflammationgenerally develops as part of the sequence of cellular events following acute inflammation. The cell types that characterize what pathologists termchronic inflammationprimarily including lymphocytes, macrophages, and plasma cells (Fig. 3.4A). These leukocytes mediate innate as well as ad...
NY. Arthritis and Pain Treatment Center is the medical arts center for immunity, inflammation, pain and regenerative diseases in Upstate of New York, the greater Albany, Schenectady, Amsterdam, Clifton Park, Saratoga Springs, Rochester, Brighton, Syracuse, Fayetteville, Binghamton, Vestal, Liverpool,...
NY. Arthritis and Pain Treatment Center is the medical arts center for immunity, inflammation, pain and regenerative diseases in Upstate of New York, the greater Albany, Schenectady, Amsterdam, Clifton Park, Saratoga Springs, Rochester, Brighton, Syracuse, Fayetteville, Binghamton, Vestal, Liverpool,...
Persistent metaflammation has been associated with the development of severe comorbidities, such as type 2 diabetes (T2D),2 nonalcoholic fatty liver disease (NAFLD),3 and atherosclerosis.4 NAFLD, a chronic and evolving liver complication, has a high prevalence of 60% in patients with T2D5; ...
(Supplementary Fig.3c). Moreover, an enlargement of the spleens and increased circulating inflammatory leukocytes were observed inFam3D−/−mice, indicating the presence of global inflammatory responses (Supplementary Fig.4a–c). These results indicate spontaneous colitis due to long termFam3D...