For the liver dysfunction we measure the liver enzymes and PAS stain on liver, electron microscopy liver mitochondria. For the assessment of intestinal inflammation we measured fecal LCN2, LPS, MPO and flagellin by ELISA and qPCR. We use confocal microscopy to detect closet bacteria near the ...
Cell debris, including damage-associated molecular patterns (DAMPs), damaged organelles, and macromolecules, are recognized and removed by the immune system. With age, cell debris accumulates due to impaired clearance and overproduction, inducing augmented inflammation and impairs tissue regeneration.42,43...
Definition of three distinct metabolic zones for hepatocytes along the sinusoids, depending on the oxygen gradient (higher near the hepatic artery and progressively lower closer to the central vein). Cellular senescence A state of permanent cell cycle arrest in which cells exit the G1 phase and en...
Near-infrared spectroscopy NLPR: NOD-like protein receptor NLRs: NOD-like receptors NO: Nitric oxide NOD: Nucleotide binding oligomerization domain OxLDL: Oxidized LDL PAMP: Protein associated molecular pattern PCAM: Platelet cell adhesion molecule ...
Finally, we analyze the potential therapeutic implications of modulators of specific inflammatory targets from the perspective of near-future translational approaches. 展开 关键词: Inflammation immune response innate immunity adaptive immunity DAMPS thromboinflammation leukocyte infiltration neurovascular repair ...
At the molecular level, PGC-1 alpha suppresses HAMP transcription via the interaction with hepatocyte nuclear factor 4 alpha. In addition, PGC-1 alpha is present near hepatocyte nuclear factor 4 alpha-binding site on the proximal HAMP promoter and turns the chromatin structure into an inactive ...
In a very similar and stereotyped sequence, the mediators are thought to induce an acute phase response orchestrated by an array of substances produced locally or near the source or origin of the inflammatory response. Despite its basically protective function, the response can become inappropriate ...
The Royal Society of ChemistryChemical ScienceHe, X.; Li, L.; Fang, Y.; Shi, W.; Li, X.; Ma, H. In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared ... X He,L Li,F Yu,... - 《Chemical Science》 被引量: 4发...
(scale for methylation 0-1, where 1 represents 100% methylation). We also standardized the regression coefficients from the multi-ethnic discovery, for example, one CpG near NF-κB inhibitor epsilon (NFKBIE) showed a decrease of 8 standard deviations of DNA methylation per standard deviations of...
Oxygen therapies used both in the delivery room and during hospitalization, immature organ development, and inflammatory/infective complications make the condition of preterm birth vulnerable to tissue injury111,112. Soon, melatonin could be used in preterm infants in the near future113,114, with the...