Certain cancers, which exhibit relatively slower growth, less invasiveness and a lower likelihood of metastasis compared to typical malignant tumors, are termed "indolent tumors." Examples include the majority of differentiated thyroid cancers and prostate cancer. Experts cautioned that while patients with...
Interestingly, the seven samples with no mutations in known CLL drivers or other cancer genes showed a lower number of ageing-associated mutations (P ¼ 0.021, Mann–Whitney test). c-AID signature exhibits classical features of SHM. Apart from the WRCY recognition motif, other previously ...
Trofosfamide as a salvage treatment with low toxicity in malignant lymphoma. A phase II study. Eur J Cancer. 1997;33(3):500–2. CrossRef Martinelli G, Laszlo D, Bertolini F, et al. Chlorambucil in combination with induction and maintenance rituximab is feasible and active in indolent non...
Encapsulated follicular thyroid tumor with equivocal nuclear changes, so-called well-differentiated tumor of uncertain malignant potential: a morphological, immunohistochemical, and molecular appraisal. Cancer Sci. 2011;102(1):288-294.PubMedGoogle ScholarCrossref 28. Howitt BE, Jia Y, Sholl LM, ...
The adult population included more high-risk patients, with more active, more frequent prior treatment (47.7% vs 11.2%; p < 0.0001), more complicated presentation (50.5% vs 35.7%; p = 0.015), more synchronous biliary cancer (11.6% vs 0%; p = 0.0118) and more major surgery (23.6% vs...
This work was supported in part by grants from the Fondo de Investigaciones Sanitarias (grant PI11/02399, Fondo Europeo de Desarrollo Regional [FEDER]) and Red Temática de Investigación Cooperativa en Cancer (RTICC; grant RD12/0036/0048, FEDER) of the Instituto de Salud Carlos III (Ministr...
kidney cancermanagementHow renal mass biopsy (RMB) impacts patient management with T1 renal masses (T1RMs) is unclear. We explore the association between RMB and utilization of active surveillance (AS), nephron-sparing interventions, and radical nephrectomy (RN).#Data were analyzed retrospectively ...
Malignant lymphoma. 1. The histology and staging of 473 patients at the National Cancer Institute. Cancer. 1982;50:2699–707. Article CAS PubMed Google Scholar Choi SI, et al. Prevalence and implications of bone marrow involvement in patients with gastric mucosa-associated lymphoid tissue ...
the cancer cell fraction (CCF) for each mutation. We plotted the fraction of mutations associated with each signature as a function of their CCF. This analysis showed that 54% of the nc-AID mutations were clonal (high CCF). As expected, therefore, the fraction of nc-AID-associated mutations...
1. A method comprising (a) identifying a subject having indolent epithelial cancer, (b) obtaining a test biological sample of the epithelial cancer from the subject and a control sample of benign noncancerous prostate tissue from the subject or from a normal subject, (c) detecting a level of...