Nevertheless, studies of disturbances of granulocyte function and the interaction of granulocytes with the plasma proteins and bacteria are vital subjects of clinical investigation not only because they reveal information concerning enhanced susceptibility to infection, but also because they help to unravel ...
TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy. Marcoe,Jeffrey,P,... - 《Nature Immunology》 被引量: 56发表: 2013年 tgf-b is responsible for nk cell immaturity during ontogeny and increased susceptibility to infection ...
tgf-b is responsible for nk cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy. Nat Immunol. 2012;13(9):843–... JP Marcoe,JR Lim...
We have previously revealed an increased susceptibility of male C57BL/6 mice towards Mycobacterium tuberculosis (Mtb) H37Rv. In the current study, we confirm the male bias for infection with the Beijing strain HN878. Males succumbed to HN878 infection significantly earlier than females. In both ...
Here we describe the recessive, loss-of-function mutation atchoum (atc) in Eif2ak4, encoding GCN2, which increased susceptibility to infection by the double-stranded DNA viruses mouse cytomegalovirus (MCMV) and human adenovirus. This mutation was identified by screening macrophages isolated from ...
infection.RESULTS:Mdr1a-/-mice exhibited a marked increase in susceptibility to T.muris infection with a 10-fold increase in colonic worm count by day 19 pi compared to FVB controls.Prior to infection,Mdr1a-/-exhibitedlow-level mucosal inflammation with evidence of an enhanced Th1 environment.T...
We here describe, in a cohort of > 170 in utero HIV-infected infants from KwaZulu-Natal, South Africa, fetal immune sex differences resulting in a 1.5–2-fold increased female susceptibility to intrauterine HIV infection. Viruses transmitted to females have lower replicative capacity (p =...
Cathepsin E-deficient (CatE(-/-)) mice showed dramatically increased susceptibility to infection with both the Gram-positive bacterium Staphyrococcus aureus, and the Gram-negative bacterium Porphyromonas gingivalis when compared with syngeneic wild-type mice, most likely due to impaired regulation of ...
Under these conditions it was found that the spread of India ink in the skin, as well as susceptibility to viral infection, was decreased in the same magnitude as obtains when the animals are treated with estrogenic hormone. The identity of effects under the two sets of circumstances seems to...
Increased susceptibility to pulmonary Pseudomonas infection in Splunc1 knockout mice. J Immunol 2013;191:4259-4268.Liu Y, Di ME, Chu HW, Liu X, Wang L, Wenzel S, et al. Increased susceptibility to pulmonary Pseudomonas infection in Splunc1 knockout mice. J Immunol. 2013;191:4259–68.Y...