There are several protocols and methodological approaches to be applied when environmental samples are tested and these are discussed in this chapter, along with the meaning and relevance of the obtained responses. Two case studies illustrate the utility of in vitro mutagenicity tests such as the ...
4.8 Bioprinting for in vitro drug testing The abovementioned have demonstrated the capacity and competency of AM to create physical (non-cellular) models, which are anatomically accurate and functional – for predicting effects of drug action and delivery. In terms of cellular models, there has...
The clinical relevance of susceptibility testing has always been questioned because of the difficulty of correlating in vitro susceptibility testing with in vivo clinical effectiveness. Clearly there have always been /pathogen factors that influence the clinical outcome that cannot be predicted by the resu...
Quality control, product performance testing and shelf life stability programs In Vitro release rate comparison testing for pre and post-changes formulations, confirm a product’s “sameness” Bioequivalence (BE) as per FDA Project specific guidances (PSG) ...
in-vitro processes. The bioaccessibility and bioavailability of As, Se and Hg species are affected by the sample matrix, cooking food and the experimental conditions applied (gastric and intestinal pH, incubation temperature and residence time). Regarding species degradation and transformation during in...
aPharmacology 药理[translate] a• Predicts compound's physiological effects (both good and bad), through both in vitro and in viva testing • 预言复合生理作用 (好和坏),通过体外和在viva测试[translate]
In vitro testing of restorative materials--what's the value? Dental professionals regularly make decisions on the selection of restorative materials for patients. These decisions are often based on the clinician's cl... J Powers - Journal of esthetic and restorative dentistry : official publication...
Knowing that some substances may lead to genotoxic entities after metabolization, there is a need for testing both the whole substance and its metabolite(s) meaning that thein vitrotest systems should include the use of metabolic activation, either endo- or exogenous which is a major source of ...
Methods The in vitro performance of the recessed-step catheter was compared to a conventional “one-step” catheter with a single transition in outer diameter (OD) at the catheter tip, and a “two-step” design comprising two distal transitions in OD. The volumes of distribution and reflux ...
In-vitro BE testing for nasal sprays products – regulatory requirements, in-vivo relevance and case studiesJernej Grmaš, Project Manager AnalyticsPresented at NIFDC IPAC-RS workshop, Beijing, ChinaSeptember 14, 2018Sandoz Development Center Slovenia...