Biomechanical testingNo standard method has been provided to define the contact point of thetibiofemoral joint of the total knee prosthesis. Our objective was to estimate thecontact point of the tibiofemoral joint in in vitro biomechanicaltesting of the total knee prosthesis. Three commercial knee ...
Grouping of chemicals based on the potential mechanisms of hepatotoxicity of naphthalene and structurally similar chemicals using in vitro testing for read-across and its validation Regul. Toxicol. Pharmacol., 121 (2021), p. 104874, 10.1016/j.yrtph.2021.104874 View PDFView articleView in ScopusGoogl...
5A). We performed single-cell ATAC-seq on MG63.3-GFP cells grown in vitro to investigate these two possibilities (Supplementary Fig. 5B). Using the above TFs as markers for the temporal accessible chromatin landscapes, we projected either (1) their motif enrichment or (2) their promoter ...
Trastuzumab is effective in the treatment of HER2/neu over-expressing breast cancer, but not all patients benefit from it. In vitro data suggest a role for
Using voltage clamp analyses of iPSCs-CMs derived from the affected child and his parents, the researchers determined that his arrhythmias were caused by theSCN5Amutation. They performed further in vitro testing using the iPSCs-CMs to identify the most appropriate regimen for correcting the aberrant...
Through systematic testing and modeling, we identified a biologically relevant in vitro condition that recapitulates antibiotic tolerance observed in ex vivo treated sputum. Ultimately, this study revealed a dominant effect of in vivo evolved bacterial populations in defining inter-subject ex vivo ...
We identify known mechanisms of drug resistance (for example, EGFR T790M—gefitinib2,61; MEK1 K57—cetuximab39,40,41) and previously unreported VUS causing drug resistance in vitro (Supplementary Table 15). We establish a framework for the functional classification of variants modulating drug ...
Linz LB, Liu S, Chougule NP, Bonning BC. In vitro evidence supports membrane alanyl aminopeptidase N as a receptor for a plant virus in the pea aphid vector. J Virol. 2015;89:11203–12. PubMed CentralGoogle Scholar Furch ACU, Van Bel AJE, Will T. Aphid salivary proteases are capable ...
In vitro overexpression of a TUBA4A cDNA carrying R320C suggested problems with microtubule assembly and disruption of axonal anterograde/retrograde transport, which may impair motor neuronal functions4. The R320C mutation may not only disrupt microtubule assembly by disfavoring polymerization of tubulin ...
1a-c] showing the existence of a deeply quiescent population in vitro. To determine whether Bz-surviving cells would also remain quiescent in vivo, RPMI8226 cells were pulsed for 24 h with Bz (8 nM or DMSO as control, n = 5 per group), washed and equal number of viable cells ...