This study investigated whether a 1.8-MHz commercial diagnostic ultrasound device has the potential to facilitate thrombolysis using an in vitro stroke model.Duplex-Doppler, continuous wave-Doppler, and pulsed wave (PW)-Doppler were compared on their impact on recombinant tissue plasminogen activator (...
Stroke penumbra defined by an MRI-based oxygen challenge technique: 2. Validation based on the consequences of reperfusion Magnetic resonance imaging (MRI) with oxygen challenge (T(2)(*) OC) uses oxygen as a metabolic biotracer to define penumbral tissue based on CMRO(2) and ox... CA Robe...
Using both an in vitro and an in vivo stroke model, the present study analyzed the therapeutic value of EVs derived from preconditioned microglia with regard to angiogenesis, anti-apoptosis, and immunomodulation. Our results suggest that OGD-preconditioning transfers microglia into the anti-inflammatory...
High-resolution micro-CT for 3D infarct characterization and segmentation in mice stroke models Raquel Pinto Jan Matula João R. Gomes Scientific Reports(2022) Advertisement Scientific Reports (Sci Rep)ISSN2045-2322(online) Sign up for theNature Briefingnewsletter — what matters in science, free ...
“During in vitro testing, we were able to dissolve an acute blood clot in well under half an hour.” Safe and effective Jiang, Shi and collaborators tested their vortex transducer in a 3D-printed model of the cerebral venous sinus. They found that a completely blocked blood vessel was ...
Dong L, Qiao H, Zhang X, Zhang X, Wang C, Wang L, Cui L, Zhao J, Xing Y, Li Y, Liu Z, Zhu C (2013) Parthenolide is Neuroprotective in rat experimental stroke model: Downregulating NF-ΚB, Phospho-P38MAPK, and Caspase-1 and ameliorating BBB permeability. Mediat Inflamm 2013:37080...
In addition, diabetic women have greater increases of cardiovascular mortality, myocardial infarction, and stroke mortality than men, compared with non diabetic subjects [65]. Overall, clinical and experimental evidence support the protective actions of endogenous estrogens towards diabetes susceptibility [...
Peptide-based scaffolds support human cortical progenitor graft integration to reduce atrophy and promote functional repair in a model of stroke Cell Rep., 20 (2017), pp. 1964-1977 Google Scholar Stukel and Willits, 2018 J.M. Stukel, R.K. Willits The interplay of peptide affinity and scaffold...
Stroke is a leading cause of long-term disability worldwide, intensifying the need for effective recovery therapies. Stem cells are a promising stroke therapeutic, but creating ideal conditions for treatment is essential. Here we developed a conductive p
The use of the murine model enables prospective study and owes the establishment of homogeneous and controlled groups. This study aimed to evaluate the effect of paternal age on in vitro embryo development at 4.5 day post conception and on in vivo fetal development at 16 days of gestation. ...