Pharmacology Actions of Protease Activated Receptors in in vivo and in vitro Models of Stroke THE CHINESE UNIVERSITY OF HONG KONG (HONG KONG) Fu Yuen Lam ZhenXiaIschaemic stroke has become one of the leading causes of death and disability in the world. Protease activated receptors (PARs, PAR-...
摘要: Departments of Neurology and Physiology and Pharmacology, Graduate Program in Neurosciences and Neurological Disorders, University of Toledo College of Medicine, Toledo, Ohio 43614, USA. trisha.dwyer@utoledo.edu关键词: Animals Humans Microglia Encephalitis Hypoxia-Ischemia, Brain Cell Culture ...
et al. A Reconstituted In Vitro Clot Model for Evaluating Laser Thrombolysis. J Thromb Thrombolysis 13, 167–175 (2002). https://doi.org/10.1023/A:1020431007864 Download citation Issue DateJune 2002 DOIhttps://doi.org/10.1023/A:1020431007864 ablation mass removal rate stroke Access this article...
Stent-thrombus interaction and the influence of aspiration on mechanical thrombectomy: evaluation of different stent retrievers in a circulation model Introduction Different devices and techniques are available for endovascular treatment of ischemic stroke. In this in vitro study, we examined the stent-th...
Assessing the early effects of OPN, we confirm that this protein impairs BBB function in vitro and demonstrate in an in vivo model of ischemic stroke that therapeutic neutralization using an anti-OPN antibody preserves the integrity of the BBB. Furthermore, the observed protection of the BBB ...
Stroke is a leading cause of long-term disability worldwide, intensifying the need for effective recovery therapies. Stem cells are a promising stroke therapeutic, but creating ideal conditions for treatment is essential. Here we developed a conductive p
Primary stentriever versus combined stentriever plus aspiration thrombectomy approaches: in vitro stroke model comparison. J Neurointerv Surg. 2015;7:453-457Maxim Mokin, Ciprian N Ionita, Swetadri Vasan Setlur Nagesh, Stephen Rudin, Elad I Levy, Adnan H Siddiqui, Primary stentriever versus ...
Indeed, preclinical stroke studies using EVs from non-stem cells hardly exist. The present study therefore analyzes the therapeutic impact of EVs derived from such preconditioned microglia under both in vitro and in vivo stroke conditions. The focus of this approach will lie on microglial M2 ...
Here, we evaluate changes of ET and 5-HT receptors, intracellular calcium levels, and calcium channel expression in rat middle cerebral artery (MCA) after focal cerebral ischemia and in vitro organ culture, a proposed model of vasoconstrictor receptor changes after stroke. Rats were subjected to ...
Ferroptosis is a newly characterized form of regulated cell death driven by iron-dependent lipid peroxidation and linked to cardiovascular disease. Ferroptosis involves various metabolic processes, including iron, lipid and glutathione metabolism. Both in vitro and in vivo evidence supports the pathophysiolo...