Our view of DNA replication has been of two coupled DNA polymerases anchored to the replication fork helicase in a "replisome" complex, synthesizing leading and lagging strands simultaneously. New evidence suggests that three DNA polymerases can be accommodated into the replisome and that polymerases ...
J. Wang, "DNA polymerases: hoogsteen base-pairing in DNA replication?" Nature, vol. 437, no. 7057, pp. E6-E7, 2005.DNA polymerases: hoogsteen base-pairing in DNA replication - Wang - 2005 () Citation Context ... a mutation at amino acid 526 (Tyr → Phe) has been shown to be ...
Our view of DNA replication has been of two coupled DNA polymerases anchored to the replication fork helicase in a "replisome" complex, synthesizing leading and lagging strands simultaneously. New evidence suggests that three DNA polymerases can be accommodated into the replisome and that polymerases ...
In eukaryotes, DNA polymerases (Pols)3 α, δ, and ϵ jointly support DNA replication, and their overall roles in this process have been defined (1). The initiation of DNA replication is catalyzed by the Pol α-primase complex, composed of the Pol α complex (p180-p70) associated with ...
Replicative DNA polymerases, such as DNA polymerase a-primase, d and e, are multi-subunit complexes that are responsible for the bulk of nuclear DNA replication during the S phase. Over the last decade, extensive genome-wide association studies and expression profiling studies of the replicative ...
Humans have four Y-family polymerases, namely polη, polι, polκ, and Rev1, and each has unique DNA-damage bypass and fidelity profiles5. Whether the bypass will be error-free or error-prone depends on the type of lesions and the overall structural features of the enzyme. Polκ is ...
Explain the role of DNA polymerases in replication. Provide a brief description and a detailed explanation of the process of DNA replication. Explain the process of DNA replication. What are the main points or most important steps in the process?
UV irradiation induces DNA damage that physically block replication fork elongation but may be bypassed by translesion synthesis polymerases. Here we have investigated the role of MUS81 after UV irradiation of human fibroblasts deficient in Polη, and restored (wild-type) cells. We show that in ...
Most current evidence indicates that DNA polymerases ε and δ, respectively, perform the bulk of leading and lagging strand replication of the eukaryotic nuclear genome. Given that ribonucleotide and mismatch incorporation rates by these replicases influence somatic and germline patterns of variation, it...
Mammalian DNA polymerases alpha and delta: current status in DNA replication. Biochemistry. 1988 Jun 28; 27 (13):4591–4595. [ PubMed ]So, A. G. & Downey. K. M. 1988 , Mammalian DNA polymerases α and δ: Current status ... AG So,KM Downey - 《Biochemistry》 被引量: 119发表: ...