Atom-to-atom mapping (AAM) is a task of identifying the position of each atom in the molecules before and after a chemical reaction, which is important for understanding the reaction mechanism. As more machine learning (ML) models were developed for retrosynthesis and reaction outcome prediction ...
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models. Nature 539, 107–111 (2016). Article CAS PubMed PubMed Central Google Scholar Gordan, J. D. et al. HIF-α effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. ...
The intramolecular cyclohexylene-bridged P/B frustrated Lewis pair [Mes(2)P-C(6)H(10)-B(C(6)F(5))(2)] 1b reacts rapidly with NO to give the persistent FLP-NO aminoxyl radical 2b formed by P/B addition to the nitrogen atom of NO. This spe... M Sajid,A Stute,AJP Cardenas,...
In which direction will the following equilibrium reaction shift in order to reestablish equilibrium if the temperature is increased? A(g) + 2B(aq) arrow 2C(g); Delta Hrxn = 25 kJ Given the following reaction: heat + CaCO3(s) ...
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Genome duplications appear to have been the principal mechanism that gives rise to multiple copies of isoenzymes. The topologies for eight of the gene trees (Figures 2, 3, 4, 5) generally reflect the 1R/2R/3R genome duplication history during vertebrate evolution. Convincing data supporting ...
It is pointed out that these bonds originate from the triangulation of the protein, and as such in general they are not chemical bonds between protein atoms: this is just a functionality of CCCPP. All figures displayed in this paper were generated with the help of PyMOL𝑇𝑀TM (The Py...
1.2.2. H2S Catabolic Pathways The catabolism of hydrogen sulfide includes non-enzymatic and enzymatic reactions. In the first reaction of a catabolic pathway, H2S is rapidly oxidized, mainly in the mitochondria and in a non-enzymatic manner, to thiosulfate; subsequently, through an enzymatic react...
The E domain is contained within the last exon in all sequences, although Nematostella has a highly divergent E domain. The gene architecture of the C-domain is well conserved in terms of both intron phases and exon sizes in all analyzed metazoans (Figure 2B). However, some conserved intron...
A plethora of concurrent cellular activities is mobilised in the adaptation of plants to adverse environmental conditions. This response can be quantified by physiological experiments or metabolic profiling. The intention of this work is to reduce the nu