Atom-to-atom mapping (AAM) is a task of identifying the position of each atom in the molecules before and after a chemical reaction, which is important for understanding the reaction mechanism. As more machine learning (ML) models were developed for retrosynthesis and reaction outcome prediction ...
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models. Nature 539, 107–111 (2016). Article CAS PubMed PubMed Central Google Scholar Gordan, J. D. et al. HIF-α effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. ...
iron pools. Excessive free iron then accelerates lipid peroxidation and the Fenton reaction, ultimately resulting in ferroptosis [40]. The degradation of ferritin is accelerated either by activating a selective cargo receptor for ferritin autophagy, nuclear receptor coactivator 4 (NCOA4), or by inhibit...
In which direction will the following equilibrium reaction shift in order to reestablish equilibrium if the temperature is increased? A(g) + 2B(aq) arrow 2C(g); Delta Hrxn = 25 kJ Given the following reaction: heat + CaCO3(s) ...
A. 护钩保护装置机能无效 B. 吊钩因长久磨损,使断面减小 C. 吊钩缺乏护钩装置 D. 吊装方法不妥 E. 超载起吊拉断钢丝绳 查看完整题目与答案 滚珠丝杠副采用双螺母齿差调隙方式时,如果最小调整量为0.0025mm,齿数Z1=61,Z2=60,则滚珠丝杠副的导程为( )mm。 A. 4, B. 6, C. 9, D. ...
Competition of different P450 species for a limited amount of CPR, which has been observed by numerous investigators (1, 2, 3, 4, 5, 6), constitutes an important element in the inter-P450 cross-talk. However, the integrative connections in microsomal monooxygenase go far beyond that and invo...
results demonstrated the proof of lunar far side volcanism 2.8 billion years ago, filling in the critical gap between 3.2 Ga and 2.0 Ga. Furthermore, a Chinese research group developed a novel method that could produce massive amounts of wa...
Transiently trapped quantum states along the reaction coordinate in the transition-state region of a chemical reaction are normally called Feshbach resonances or dynamical resonances. Feshbach resonances trapped in the HF–OH interaction well have been d
Current antibody-drug conjugates (ADCs) target internalising receptors on cancer cells leading to intracellular drug release. Typically, only a subset of patients with solid tumours has sufficient expression of such a receptor, while there are suitable n
It is pointed out that these bonds originate from the triangulation of the protein, and as such in general they are not chemical bonds between protein atoms: this is just a functionality of CCCPP. All figures displayed in this paper were generated with the help of PyMOL𝑇𝑀TM (The Py...