The glutaminase enzymes GAC and GLS2 catalyze the hydrolysis of glutamine to glutamate, satisfying the ‘glutamine addiction’ of cancer cells. They are the targets of anti-cancer drugs; however, their mechanisms of activation and catalytic activity have
Sirtuins (SIRTs), enzymes from the family of NAD+-dependent histone deacetylases, play an important role in the functioning of the body at the cellular level and participate in many biochemical processes. The multi-directionality of SIRTs encourages scie
This raises the question about the clinical significance of DNA2 in cancer. Int. J. Mol. Sci. 2017, 18, 1562 11 of 20 Cancer microarray data identified enhanced expression of DNA2 at mRNA and protein levels in cancer cells [104,105]. Enhanced DNA2 expression was also observed strongly ...