Here mathematical modeling, with known experimental\nparameters, is used to show that the binding of a stabilizing factor, such as\ntalin, is alone insufficient to enable ligand-dependent integrin activation for\nall observed conditions; an additional positive feedback is required....
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but in ICANS the activation of endothelium causes weakening of the BBB, shown here with degenerating astrocyte foot processes, allowing for the entrance of Monocytes, and CAR-T into the CSF. This results in a localized positive feedback loop in the CNS ...
In today’s world, customer feedback comes from a variety of sources. From dynamic social media to the ever-prominent email, customer feedback can take any form. No matter if you set up a mechanism or not, customers will surely talk about the business and the products and services they ...
Eventually, degraders and non-degraders, at the sub-population ratio (100:1), generated a positive feedback loop via mutualistic cross-feeding interactions. Interestingly, when the populations of non-degraders were artificially increased to levels similar to the degrader, the reconstructed communities ...
experiments demonstrated that bladder inhibition takes place, even though the urethral striated musculature was made paralytic with succinylcholine.17 Finally, neuro transmitters may also be involved: the sacral para sympathetic pathway to the urinary bladder is essentially a positive feedback ...
culture was significantly enhanced by ~2 folds through relevant metabolite supplements (Fig.4D). In contrast, the addition of metabolites did not significantly improve the growth in the two controls, and even inhibitedP. gergoviaegrowth (Fig.4D). This demonstrated that the positive roles of ...
Cells have a feedback mechanism in which free intracellular cholesterol inhibits HMGCR activity and the uptake of LDL through LDLR. As cancer cells require high levels of cholesterol, elevated LDL uptake is often seen in cancers, as well as upregulation of LDLR, NPC1, SREBP-2, and the enzyme...
The feedback mechanism between the hypothalamus and adipose tissue that maintains hypothalamic NAD+ levels through the secretion of eNAMPT.36 In adipose tissue, iNAMPT is acetylated, and SIRT1 specifically deacetylates lysine 53 and predisposes iNAMPT to secretion in a NAD+-dependent manner. eNAMPT...