www.nature.com/scientificreports OPEN Significant impact of miRNA–target gene networks on genetics of human complex traits received: 28 October 2015 accepted: 01 February 2016 Published: 01 March 2016 Yukinori Okada1,2, Tomoki Muramatsu3, Naomasa Suita1,4, Masahiro Kanai1, Eiryo ...
migration of DU-145 and PC-3 cells over 48 h (hr) and MDA-MB-231 cells over 24 h compared to controls. GNS-BSA inhibited cell migration over 48 h (hr) for DU-145 and over 24 h for PC-3 and MDA-MB-231. Adhesion assay showed a moderate reduction of PC-3 adhesion ability (∼...
It has a trisaccharide structure with two N-linked sugar chains on both the α and β subunits and four O-linked sugar chains on the β subunit, with a molecular weight of 36.7 kDa, and it is secreted by placental trophoblast cells [17]. It is now common to use hCG test strips to ...
The database access on PubMed makes it easy to judge a relevant scientific theme of important concern. As exemplified in Figure 1, a timeline search on PubMed with the title, “nanoparticle and corona” disclosed > 2000 publications from the years 2000 to 2020, and this number has increased...
and the cells were incubated for 4 min in a 37 °C and 5% CO2humidified incubator. In the flask, 4 mL of DMEM/10% FBS were added and pipetted up and down for 1 min to ensure that all the cells were evenly suspended before seeding in different plate formats based on the experiment ...
Importantly, overexpression of MEK5-DD or KLF4 in H2O2-stressed cells upregulated the expression of anti-apoptotic proteins such as Bcl-2 and neuronal apoptosis inhibitory protein-2, and downregulated the expression of pro-apoptotic proteins such as Bax and Caspase 1 [181]. Based on the above ...
Through transcription-coupled nucleotide excision repair (TC-NER), Philip Hanawalt’s lab first showed the repair of bulky lesions induced by UV damage from the transcribed strand of the active gene. However, these lesions could not be repaired in the cells of individuals with Cockayne syndrome ...
molecules Article Cyclodextrins: Assessing the Impact of Cavity Size, Occupancy, and Substitutions on Cytotoxicity and Cholesterol Homeostasis Lajos Szente 1, Ashutosh Singhal 2,3 ID , Andras Domokos 4 ID and Byeongwoon Song 2,3,* 1 Cyclolab Cyclodextrin Research and Development Laboratory Ltd., H...
One of the key factors that has hampered progress in defining an ambitious target is the lack of thorough studies that assess the technical possibility of decarbonizing international maritime transport, especially according to the more ambitious goal of the Paris Agreement—i.e., the 1.5 ◦C ...