drugs and medicationsSummary Hazardous alcohol use and chronic liver disease are common conditions that may frequently coexist. Both can profoundly alter the metabolism of drugs. Clinicians should be aware of the potential consequences of altered metabolism when considering prescribing for such patients. ...
The review mainly discusses the impact of alcohol on the drug metabolism and alcohol-drug pharmacokinetic interactions. Many drugs can interact with alcohol, thereby altering the metabolism or effects of alcohol on the drugs. Drugs may affect the pharmacokinetics of alcohol by altering gastric emptying...
Excess food intake and alcohol can each increase intrahepatic lipid yet, the two are commonly consumed together. Few studies have assessed the combined effects of overeating and excess alcohol intake, both of which stimulate hepatic de novo lipogenesis (DNL) and have the potential to increase ...
This study aimed to provide a better understanding of the impact of paclitaxel chemotherapy on breath alcohol in an Irish population. Patients attending th
On the basis of reports by his wife, she had accidentally mixed Roundap in his alcohol, and he had ingested between 350 and 500 mL of rum Roundup. About two hours after ingestion, she found him with altered mental status, non-bilious vomiting, and difficulty to wake, but he did not ...
Chronic Obstructive Pulmonary Disease (COPD) and Non-Alcoholic Fatty Liver Disease (NAFLD) both independently increase cardiovascular risk. We hypothesized that NAFLD might increase the incidence of cardiovascular disease and death in COPD patients.
Molecular networks regulating the conversion of TAMs from M2 to M1 polarization have been identified as potential targets for therapeutic intervention in HCC. Various drugs and compounds targeting TAMs and suppressing their M2 phenotypes or tumorigenesis activity have been explored as potential therapeutic ...
Histopathological impact of SARS-CoV-2 on the liver: Cellular damage and long-term complications. World J Gastroenterol 2024; 30(22): 2866-2880 URL: https://www.wjgnet.com/1007-9327/full/v30/i22/2866.htm DOI: https://dx.doi.org/10.3748/wjg.v30.i22.2866 ...
This paper presents insights from three research activities from the preparatory phase of the development of a new self-report health and functioning measure. A scoping literature review was conducted to identify the positive and negative impact of TNP use on health and functioning. Focus groups (n...
The model was adjusted by the following covariates: age, gender, decompensated cir- rhosis, Charlson comorbidity index, abuse of alcohol and/or drugs, number of organ failures, and site of infec- tion (see Additional file 1 SDC). This semi-parametric model provided the survival probabilities ...