Cell death mediated by genetically defined signaling pathways influences the health and dynamics of all tissues, however the tissue specificity of cell death pathways and the relationships between these pathways and human disease are not well understood. We analyzed the express...
et al. Interferon regulatory factor 3 activates p53-dependent cell growth inhibition. Cancer Lett. 242, 215–221 (2006). Article CAS PubMed Google Scholar Galluzzi, L., Buque, A., Kepp, O., Zitvogel, L. & Kroemer, G. Immunogenic cell death in cancer and infectious disease. Nat. Rev...
leading to recruitment of guanine nucleotide exchange factor (GEF) by Src homology 2 domain containing transforming protein (SHC) and growth factor receptor-bound protein 2 (GRB2), which substitutes GDP with GTP to activate RAS. Once in its active state, or in the case ...
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting. Cell Metab. S1550-4131, 00090–00090 (2022). Google Scholar Hughes, D. A. et al. Genome-wide associations of human gut microbiome variation and implications for causal ...
Hyperactive coagulation might cause dangerous complications such as portal vein thrombosis and pulmonary embolism after mesenchymal stem/stromal cell (MSC) therapy. Tissue factor (TF), an initiator of the extrinsic coagulation pathway, has been suggested as a predictor of this process. Methods The expr...
Programmed cell death 1 (PD-1) and one of its ligands, PD-L1, are key immune checkpoint proteins. Evidences showed PD-L1 is an emerging biomarker for immun... ZK Pan,Y Feng,W Xuan,... - 《Journal of Thoracic Disease》 被引量: 75发表: 2015年 Molecular Determinants of Response to An...
IL-15 appears to prolong survival via the anti-apoptotic factor Bcl-2 [28]. NK cells also play a role in the interactions between innate and adaptive immune responses. NK cell function and dynamics may be affected by ageing. Age-related reductions in NK-cell-mediated cytotoxic activity appear...
The majority of the 'cell death' genes were disease resistance (R) genes encoding nucleotide-binding site leucine-rich repeat (NBS-LRR) proteins, the most abundant class of R-proteins which are involved in pathogen recognition and signaling initiation [42, 43]. Although protein kinases, which ...
The impact of genetic variation on overall disease burden has not been comprehensively evaluated. We introduce an approach to estimate the effect of genetic risk factors on disability-adjusted life years (DALYs; ‘lost healthy life years’). We use genet
Coronavirus disease 2019 (COVID-19) is a severe acute respiratory syndrome caused by Coronavirus 2 (SARS-CoV-2). In the light of its rapid global spreading, on 11 March 2020, the World Health Organization has declared it a pandemic. Interestingly, the gl