reviews dealing with hot aspects of cancer such as the role cell death regulators, exosomes, metabolism, and long non-coding RNAs and their possible implications in therapy1,2,3,4. The fifth contribution encompasses the recent developments in the field of metabolic diseases such as non-alcoholic ...
The liver is not oblivious to the passage of time, as ageing is a major risk factor for the development of acute and chronic liver diseases. Ageing produces alterations in all hepatic cells, affecting their phenotype and function and worsening the progno
“Cell Death & Diseaseis celebrating its 10th anniversary. In the last 10 years from its foundation the content ofCell Death & Diseasehas covered an enormous breadth of subjects at the forefront of experimental medicine and clinical practice. The Journal’s mission aims to encompass the breadth o...
NK cells are first-line defenders of the immune response against infectious diseases [3] and cancer [4] but they are also important in autoimmune [5,6] and metabolic diseases [7]. They provide rapid responses because they do not require prior priming. They recognize target cells using germlin...
Over the past decade, numerous studies have indicated that different forms of regulated cell death (RCD) are connected with mitophagy. These diverse forms of RCD have been shown to be regulated by mitophagy and are implicated in the pathogenesis of a variety of diseases, such as tumors, ...
International Journal of Molecular Sciences Review Cell Death in Liver Diseases: A Review Layla Shojaie 1,2 , Andrea Iorga 1,2 and Lily Dara 1,2,* 1 Division of Gastrointestinal & Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles,...
Cell death pathway genes Fas FasL polymorphisms Non small cell lung cancer PCR-RFLP 1. Introduction Lung cancer is claimed to be one of the leading causes of cancer related deaths over the world [1]. Since 1985, it has been the most common cancer diagnosed each year [2]. Respiratory syste...
Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death...
If pathophysiology were a fan propeller, cell death would constitute the pivot. Indeed, most diseases are connected to deregulated cell death in some way. Excessive, unwarranted cell death accounts for pathological cell loss, be it slowly degenerative as in Alzheimer's disease or dramatically acute...
Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-survival and pro-death pathways in malignant, stromal, endothelial and immune cells, hence causing a profound cellular and biological reconfiguration via multiple, non-redundant mechanisms. Such mechanisms include the ...