Immune cells in the TME can predict resistance to PD-1 inhibitors, the backbone of immunotherapy. When PD-1 inhibitors are used, PD-1 + Tregs exhibit broader inhibition of antitumor immunity, leading to drug resistance [45]. In addition, M2-like TAMs [148] and CAFs [149] may predict...
A unique T cell stress response state, TSTR, was linked to immunotherapy resistance. Our high-resolution T cell reference maps, web portal, and annotation tool can assist efforts to develop T cell therapies. Resource | 29 May 2023 Pan-cancer T cell atlas links a cellular stress response ...
a large proportion of patients have been described to resist and not respond to these new treatments.The new incoming challenge is now therefore to overcome these resistance and new recent data presented epigenetic modifications as promising targets to restore anti-tumor immunity.Indeed,both DNA ...
1. therapy designed to produce immunity to a disease or to enhance resistance by the immune system 行业词典 医学 免疫疗法:用另一个体中主动产生的抗体(血清或丙种球蛋白)使某一个体产生被动免疫。广义说,本术语包括主动和被动免疫接种,用免疫强化剂和抑制剂治疗,为变应性疾病减敏,骨髓移植和胸腺植入等 ...
(MDSCs), are involved in TME modulation to cause immunotherapy resistance. This review highlights the role of stromal cells in modulating the breast tumor microenvironment, including the involvement of CAF-TAM interaction, alteration of tumor metabolism leading to immunotherapy failure, and other latest...
Our results revealed that high ITH was associated with poor patient survival and immunotherapy resistance. Importantly, we identified zinc finger protein 689 (ZNF689) deficiency as a crucial determinant of ITH formation. Mechanistically, the ZNF689–TRIM28 complex was found to directly bind to the ...
sustained immune action after cessation of therapy, which may lead to continued antitumor effects and sustainedoverall survival.9There is some evidence that tumors that initially respond to immune therapy may become resistant over time. Trials to develop therapies to combat immunotherapy resistance are ...
Interferon signaling mediates resistance to immune checkpoint blockade therapy, but the underlying mechanisms are poorly understood. In this issue of Immunity, Cucolo etal. identify RIPK1 as an interferon-stimulated gene with potent effects on cell extrinsic and intrinsic immunotherapy resistance. Copyright...
Resistance: How to resist immunotherapyDespite the great progress in our understanding of the molecular basis of human cancer, the heterogeneity of individual tumors and the evolutionary pressures imposed by therapy have hampered our ability to effectively eradicate and control this disease. How, ...
Immunotherapy is the treatment of disease by inducing, enhancing or suppressing an immune response. Activation immunotherapies induce or amplify an immune response and are used in vaccines and as cancer immunotherapies. Suppression immunotherapies reduce or suppress an immune response and are used to prev...