Therefore, we aim to elucidate the ICB resistance mechanisms mediated by the activation of the IL-8/CXCR2 pathway. Single-cell RNA sequencing (scRNA-seq) were performed in advanced HCC patients with baseline and on-treatment biopsy after pembrolizumab in a Phase II clinical trial cohort. Our ...
limiting its efficacy in many patients. Circular RNAs (circRNAs), a novel class of non-coding RNAs, have emerged as pivotal regulators of gene expression and cellular processes. Increasing evidence indicates their involvement in modulating resistance to cancer immunotherapy. Notably, certain...
A deeper understanding of resistance mechanisms and factors that predict therapeutic response are urgently needed to stratify patients and to avoid unnecessary treatment.12,17,[30], [31], [32] Herein, we review what insights single-cell analysis has revealed about the heterogeneity of HCC and how...
Potential molecular, cellular and microenvironmental mechanism of sorafenib resistance in hepatocellular carcinoma. Cancer Lett. 2015;367(1):1–11. doi:10.1016/j.canlet.2015.06.019 (Open in a new window)PubMed (Open in a new window)Web of Science ®(Open in a new window)Google Scholar...
IFNγ signalling has been described as a potential driver of resistance to immune checkpoint blockade (ICB) therapy. Here the authors report that PARP14 is upregulated in chronic IFNγ-treated cancer cell models and that its inhibition restores response to anti-PD-1 therapy in preclinical cancer...
. Hence, the selective target of myeloid cells-derived Siglec-15-mediated immune suppression can improve the therapeutic efficacy of PD-1/B7-H1 blockade strategy which then represents acquired resistance in the aspect of several human cancers [76,77]. A recent study by Jun Wang’s group ...
Understanding the drug resistance mechanism is necessary to improve the efficacy of anti-PD-1[63]. PD-1, also known as CD279, is an immunosuppressive molecule [64]. In HCC, Binding of PD-1 to ligand triggers downregulation of T cell receptor, inhibits T cell activation and cytokine ...
resistance can emerge through different mechanisms such as limitation of intracellular concentration of ADC, downregulation of target antigens, reduction of internalization of ADC, increased ADC recycling to mask the antigen epitopes, or activation of alternative signal pathways. Class side effects are ...
Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC. Nat Commun. 2019;10(1):4681. 111. Singer M, Wang C, Cong L, Marjanovic ND, Kowalczyk MS, Zhang H, et al. A distinct gene module for dysfunction uncoupled from activa- ...
In addition to low molecular weight, specific binding to targets, resistance to temperature, pH, and enzymes, high ability to penetrate tumor tissues, and low toxicity make nanobodies an ideal approach to overcome the disadvantages of monoclonal antibody-based immunotherapy. In this article, while ...