The occurrence of serious side effects from such therapy is a resultant from host condition, duration and dosage of drug exposure. The most impressive demonstration ofimmunosuppression and its side effects as well as beneficial effects is observed in marrow graft recipients who undergo bone marrow ...
often with the additional involvement of the posterior temporal, parietal, orfrontal lobes(Fig. 16).56Additional structures such as thebrainstem,cerebellum, andbasal gangliacan also be affected.56Most patients usually have a full gradual resolution of symptoms after drug withdrawal, and imaging abnorma...
These side effects can be too difficult to handle. Extreme ones include temporary reduction in white blood cell count and red blood cell count. This increases the risk of infection and anemia. The other side effects of this drug includenausea, vomiting, hair loss, rash, and darkening of the ...
Immunosuppressive drugAn immunosuppressive drug comprising an anti-estradiol antibody as an effective ingredient. The drug of the present invention has a clear immunosuppressive activity and does not have serious side effects or toxicity. KEISUKE HIRASAWA ...
Some patients, however, are dependent on low-dose corticosteroids, and relapse when the drug is withdrawn. These drugs have widespread actions on the immune response, and monocytes are particularly sensitive to corticosteroids. In contrast, sulphasalazine and 5-aminosalicylic acid are effective in ...
I see patients who are not immunosuppressed potently enough, not treated long enough, or are treated without adequate management of side effects or infections. The predictably poor outcomes may end up souring both the patient and physician on a particular drug or convincing both that it is ineffec...
P-glycoprotein and Drug Therapy in Organ Transplantation The objective of this review is to discuss the effects of P-gp modulation on the pharmacokinetics and the pharmacodynamics of immunosuppressive agents such ... Agnes,Lo,Gilbert,... - 《Journal of Clinical Pharmacology》 被引量: 34发表: 201...
immunosuppressive drug,any of a variety of substances used to prevent production ofantibodies. They are commonly used to prevent rejection by a recipient's body of an organ transplanted from a donor. A transplant is rejected when the recipient's immune system acts against it; current methods aim...
The risk of complications appears to depend on drug dosage, treatment duration, and patient characteristics, the highest rate of serious side effects (20%) having been found in late-onset MG and the lowest (4%) in early-onset disease. Although nonspecific, current immunosuppressive treatment is ...
Treatment combining transplantation of MSCs with immunosuppressive drug application ranks among the very promising new therapeutic strategies aiming to reduce immunosuppressant doses, eliminate their adverse effects and to improve their action. Although the suppressive effects of MSCs cultured in combination ...