AbstractEndothelin (ET) signaling provokes nephrotoxicity induced by the immunosuppressant drug cyclosporine A (CSA). We tested the hypotheses that (i): celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, counterbalances renal derangements caused by CSA in rats and (ii) the COX-2/endothelin...
We also observed a richer profile of gut bacterial in moderate AD patients. The longer interval between AD flares, less use of antimicrobials due to fewer bacterial infections, and absence of immunosuppressant drugs in moderate AD patients compared to severe AD patients could explain the richer ...
involving all these external cellular and humoral elements, has become a hallmark of cancer26. BC is less immune-activated than many other “hot” tumor types, such as melanoma, bladder or some lung cancers, in part related to fewer immunogenic tumor antigens and non-synonymous (amino acid...
However, the biological role of IDO2 and its relationship with IDO1 are unknown. To assess the relationship between IDO2 and IDO1, we investigated the effects of co-expression of human (h) IDO2 on hIDO1 activity. Cells co-expressing hIDO1 and hIDO2 showed reduced tryptophan metabolic ...
Direct immunosuppressant effects of streptozotocin in mice. Diabetologia. 1979, 16 (1): 51-57. 10.1007/BF00423151. Article PubMed CAS Google Scholar Thomsen RW, Jepsen P, Sorensen HT: Diabetes mellitus and pyogenic liver abscess: risk and prognosis. Clin Infect Dis. 2007, 44 (9): 1194-...
“immune surveillance”); the equilibrium phase, in which the immune system maintains control over cancer cells with a balance between the production of immunostimulants (e.g., interleukin [IL] 12) and immunosuppressants (e.g., IL23) and the escape phase, in which the tumor cells escape ...
Given the growing role attributable to lymphocyte activation and function in the treatment of solid tumours, the availability of active paclitaxel without the need for administration of immunosuppressant steroids is very attractive for combination with immunomodulatory drugs such as atezolizumab. The dose ...
Calcineurin plays a pivotal role in the T cell receptor (TCR)-mediated signal transduction pathway and serves as a common target for the immunosuppressants... S Luo,HD Youn,C Loh,... - 《Immunity》 被引量: 529发表: 1998年 X-linked Inhibitor of Apoptosis (XIAP) Inhibits c-Jun N-termina...
Current therapies for OM are ineffective due to the emergence of antibiotic-resistant NTHi strains and risk of side effects with prolonged use of immunosuppressant drugs. In this study, we show that curcumin, derived from Curcuma longa plant, long known for its medicinal properties, inhibited NTH...
recurrence and diverse systemic negative side effects5. Consequently, there is a great demand to develop new therapy regimens with new drugs such as multi-target inhibitors which could be a single drug with multiple inhibitory effects or combinational therapy of more than one drug so as to simulta...