However, supplemental α-TA at the doses of ⩾1050 IU/kg diet prevented the SSCS-induced body weight loss and lung dysfunction. α-TA at ⩾5550 IU/kg significantly increased BAL levels of IL-2 and IL-4 in both the sham SSCS and the SSCS groups. Given at 5550 IU α-TA/kg, but...
The pathological changes of liver tissue and apoptosis of hepatocytes were also assessed. RESULTS: In in vitro MLC, T lymphocyte proliferation in Wistar rats was significantly inhibited by 48.44%. In the MSC-treated group, the levels of ALT, AST, TBIL, IL-2 and IL-10 were 134.2±45.0 U...
salivarius CECT 9609 to combat this infection at the molecular level with minimal negative effects on the biology/physiology of the airway epithelia. In addition, we characterize at the cellular and molecular level the infection mediated by Pasteurella multocida in airway epithelia at early stages....
such as IL-17, IL-1β, IL-6, IL-3, IL-8, IL-21, IL-22, IL-7, IFN-γ, TNF-α, and IL-12, among others. After PNI, pro-inflammatory factors such as IL-1, IL-2, IL-6, and TNF-α are expressed during the first stage of Wallerian degeneration...
In addition to their role as antiviral cytokines, type I IFNs have a wide range of immunomodulatory effects in response to bacterial infections. Type I IFNs are implicated in different autoimmune and inflammatory conditions, although their role in each condition varies. Some autoimmune diseases are...
Effects of insulin in relatives of patients with type 1 diabetes mellitus. N. Engl. J. Med. 346, 1685–1691 (2002). Di Lorenzo, T. P., Peakman, M. & Roep, B. O. Translational mini-review series on type 1 diabetes: systematic analysis of T cell epitopes in autoimmune diabetes. ...
activation, IFN-γ-licensed MSCs dramatically reduced IL-6 and IL-10 levels secreted by T-cells exposed to NS antigens and iCM. Moreover, IFN-γ-licensed MSCs were able to significantly inhibit T-cell apoptosis induced by SARS-CoV-2 NS antigens. Taken together, our data show that, in ...
9, 10 We demonstrate up-regulation of the IL-2Rβ (CD122) subunit by both RAR and RXR rexinoids in T cells, but more selective effects in B cells, with up-regulation of IL-2Rβ (CD122) but not IL-2Rα (CD25) expression. In both Sezary T-leukemia cells and B cells of ...
Briefly, the regulatory effects of probiotics on host immune responses are followed through activation of the function of dendritic cells, macrophages, and T and B lymphocytes [15,16]. In addition, probiotics have proved to modulate and regulate innate and adaptive immune responses partly through ...
Lactoferrin (Lf) is an iron-binding glycoprotein of the transferrin family, which is expressed in most biological fluids with particularly high levels in mammalian milk. Its multiple activities lie in its capacity to bind iron and to interact with the mo