Synonyms p47 GTPases Historical Background The IRGs are a family of proteins that play critical roles in innate immune responses to intracellular pathogens (Martens and Howard 2006 ; Shenoy et al. 2007 ; Taylor 2007 ). IRG cDNAs were discovered independently by several scientists who were ...
The immunity-related GTPases (IRGs) are a family of proteins induced by interferon-γ that play a crucial role in innate resistance to intracellular pathogens. The M subfamily of IRG proteins (IRGM) plays a profound role in this context, in part because of the ability of its members to ...
Immunoblots of lysates of primary hepatocytes isolated from3xFlag-Gm4951knockin mice. Different doses of IFNγ were added into the medium for 24 h. Gapdh was used as a loading control.kLuminescence to quantitate the amount of GTP remaining 1 h after the GTPase assay with different concen...
This has been linked to the upregulation of several hundreds of IFN-stimulated genes, among them the so-called IFN-inducible GTPases. Two subfamilies of IFN-inducible GTPases, the immunity-related GTPases (IRGs) and the guanylate-binding proteins (GBPs), have gained attention due to their...
C. Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNγ-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death. PLoS Pathog. 5, 6 (2009). Google Scholar Martens, S. et al. Mechanisms regulating the positioning of mouse p47 resistance GTPases LRG-47 ...
Bacterial phagosome acidification within IFN-gamma-activated macrophages:role of host p47 immunity-related GTPases IRGs). Tiwari S,Macmicking JD. Methods in Molecular Biology . 2008Tiwari S., Macmicking J. D. (2008) Methods Mol. Biol. 445 , 407–415...
Phagocytosis through Dectin-1 is also actin dependent and, therefore, Rho-family GTPases and nucleation-promoting factors like WASP are presumably also recruited to phagocytic cups containing yeasts/fungi. While much less is known about the specific signaling pathways elicited by Dectin-1, a recent...
Interferon (IFN)-inducible GTPases currently include four families of proteins: myxovirus resistant proteins (Mxs), guanylate-binding proteins (GBPs), immu... G Li,J Zhang,Y Sun,... - OXFORD UNIV PRESS 被引量: 72发表: 2009年 Discrete two-sex models of population dynamics: On modelling ...
The IFN-inducible protein Irgm1 (LRG-47) belongs to the family of immunity-related GTPases that function in cell-autonomous resistance against intracellular pathogens in mice. Irgm1 deficiency is associated with a severe immunodeficiency syndrome. The protein has been variously interpreted as a direc...
Related links DATABASES OMIM CHS FHL Griscelli syndrome HPS FURTHER INFORMATION Jennifer Stow's homepage Glossary Endocytic pathway The pathway by which proteins and lipids from the cell surface and extracellular milieu are internalized into membrane-bound compartments and either recycled back to the surf...