(ICD). A form of cell death that leads to the recognition of dead-cell antigens by T lymphocytes. Immunogenicity The capacity of an entity to induce an immune response based on the combination of antigenicity and adjuvanticity. Integrated stress response (ISR). A phylogenetically ancient stress...
Immunotherapy has been identified in a recent decade to be a promising solution of ultimate cancer therapy, but most of the reported SNAs, to our knowledge, have shown only immunogenic cell death (ICD) properties based on the use of a single chemotherapeutic drug, which is insufficient for ...
Therefore, a positive shift in the cancer-immunity cycle contributing to the success of anti-tumor immunity by utilizing ICD agent, mild PTT, antigen-capturing liposomes and PD-L1 antibody is very important for combination cancer treatment [29,35]. In consideration of these strategies, we ...
ICD: Immunogenic cell death IRE-1α: Inositol-requiring enzyme-1α Kdelr1: KDEL receptor 1 LOX-1: Lectin-type oxidized LDL receptor-1 M-MDSC: Monocytic MDSC MDSC: Myeloid-derived suppressor cells Nrf2: NF-E2-related factor-2 PERK: Pancreatic ER kinase (PKR)-like ER kinase PKR...
(S2I), Coimmunoprecipitation assays of HER2 and STING truncations showed that the intact C-terminal domain (CTD) (a.a. 139-379) of STING and the intact ICD of HER2 were necessary and sufficient for their interaction. (S2J), K63-linked ubiquitination, an indicator of TRAF6 activation, was...
Induction of Immunogenic Cell Death Although apoptosis is classified as an immunologically silent form of cell death, certain anti-cancer chemotherapy drugs can induce an immunostimulatory form of cell death, called immunogenic cell death (ICD). Indeed, various anti- myeloma drugs, such as ...
More importantly, the induced ICD will reactivate the anti-cancer immunity and enhance tumor suppression by M1--polarizing macrophages and infiltrating cytotoxic CD8+ T cells into the tumor, in synergy with the TZP-initiated chemotherapy. Access through your organization Check access to the full text...
CD8+ T cell adjuvant effects of Salmonella FliCd flagellin in live vaccine vectors or as purified protein 2010, Vaccine Citation Excerpt : Heterologous prime-boost immunization regimens usually consist in a priming step with one vaccine type, such as naked DNA, and a subsequent boost with a diff...
The Annexin V and PI stain was used check the cell apoptosis and death. With our experimental setup, long-lived species and electric field generated by the plasma did not have significant effects on either the normal or cancer skin cells. In contrast, the short-lived species significantly ...
Argonaute 4a, known to be involved Viruses 2018, 10, 587 12 of 21 in DNA methylation, was also found to be upregulated. Mapping quality check allowed us to rule out the expression of argonaute 2b and 3 in this study. Argonautes 1, 5, 6, 7, and 10 were found to be present but ...