(ICD). A form of cell death that leads to the recognition of dead-cell antigens by T lymphocytes. Immunogenicity The capacity of an entity to induce an immune response based on the combination of antigenicity and adjuvanticity. Integrated stress response (ISR). A phylogenetically ancient stress...
a Deaths with confirmed or presumed COVID-19, coded to ICD–10 code U07.1. 3. Role of natural forces, like seasonal change Pandemics can fizzle out. We hope this will happen with COVID-19. This is not a public health intervention and not in Table 1. In the Spanish flu epidemic there...
The database contains demographic data, in- and outpatient diagnoses recorded according to the International Classification of Diseases (ICD-10-GM), in- and outpatient diagnostic and therapeutic procedures, and outpatient drug prescriptions. Outpatient diagnoses can only be allocated to a quarter of a...
Finally, he focused on a newly identified pro-tumor subset of F4/80hiCD115hiC3aRhi TAMs expressing the heme-oxyge- nase 1 enzyme and involved in iron metabolism. This subset favors immunosuppression, angiogenesis and epithelial-to- mesenchymal transition. F4/80hiCD115hiC3aRhi TAMs orig- inate ...
(S2I), Coimmunoprecipitation assays of HER2 and STING truncations showed that the intact C-terminal domain (CTD) (a.a. 139-379) of STING and the intact ICD of HER2 were necessary and sufficient for their interaction. (S2J), K63-linked ubiquitination, an indicator of TRAF6 activation, was...
However, the relationship between ICD and ACSL4-mediated ferroptosis is poorly understood in AML. As such it is highly desirable to explore whether ACSL4-mediated ferroptosis can increase cancer cell immunogenicity in AML. Here, we report that propionate could induce ferroptosis and apoptosis. And ...
Overall, this well-designed tumor ISV demonstrates a precise and efficient synergistic immunotherapy strategy that combines ICD induction with STING pathway modulation to activate potent antitumor immunity. Scheme 1 Access through your organization Check access to the full text by signing in through your...
Immunogenic cell death (ICD) is a unique cell death pathway associated with endogenous danger signals released by dying cells, which has been proven in recent years to be triggerable by chemotherapy and ROS-induced cell damage [35], [36]. The robust tumoral ICD will stimulate the exposure of...
A single round of chemo-photothermal therapy with PCLA-ID triggered immunogenic cell death (ICD) and enhanced antitumor immunity, leading to improved survival for a metastatic breast cancer model. In addition to eliminating the primary tumor, the combinatorial treatment of PCLA-ID and PTT induced ...
Therefore, a positive shift in the cancer-immunity cycle contributing to the success of anti-tumor immunity by utilizing ICD agent, mild PTT, antigen-capturing liposomes and PD-L1 antibody is very important for combination cancer treatment [29,35]. In consideration of these strategies, we ...