Background Immune thrombocytopenia (ITP) is an acquired form of thrombocytopenia seen in adults and children. It is characterized by immune-mediated platelet destruction and can lead to life-threatening bleeding in certain patients. Protein-energy malnutrition (PEM) can lead to adverse outcomes in ...
Indeed, a peculiar immune complex mechanism is responsible for the thrombocytopenia occurring in heparin-induced thrombocytopenia (HIT). HIT differs from most other forms of drug-induced immune thrombocytopenia in that the responsible antibodies bind to complexes resulting from noncovalent interaction of a...
Secondly, valuable insights into normal hematopoiesis can be gleaned from evidence concerning abnormal hematopoiesis. Investigations involving mice and humans focusing on the pathogenesis of idiopathic thrombocytopenic purpura (ITP) and prolonged isolated thrombocytopenia (PT) have unveiled a notable increase i...
Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clin. Chim. Acta 2020, 506, 145–148. [CrossRef] 54. Lippi, G.; Plebani, M. Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): A meta...
·4 months), and also achieved ORR (11 patients versus 1 patient) [148]. Likewise, combined use of nivolumab plus gemcitabine and cisplatin induced favorable effects in BTC patients concomitant with some grade 3 or higher adverse events such as thrombocytopenia (56%) and neutropenia (22%) [...
Hematological side effects of immune checkpoint inhibitors: the example of immune-related thrombocytopenia. Front Pharmacol. 2019;10:454. 17. Lombardi A, Mondelli MU. Review article: immune checkpoint inhibi‑ tors and the liver, from therapeutic efficacy to side effects. Aliment Pharmacol Ther. ...
Unfortunately, the current ICD-10 version (ICD-10 2019) still uses the term “idiopathic thrombocytopenic purpura” for D69.3.According to international agreement, ITP should only be diagnosed when the platelet count is repeatedly below 100,000/µL. The reason is that mild thrombocytopenia ...
Chronic ITP cases were defined as patients with at least two diagnoses (ICD-9 code 287.3) for primary thrombocytopenia separated by at least 6 months between 2002 and 2006. A patient sfi rst identified 287.3 ICD-9 code over the period 2002鈥 2006 had to be in 2004 or earlier and the ...
Background: Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP) is a rare and life-threatening condition characterized by microangiopathic hemolytic anemia, thrombocytopenia, and organ dysfunction. Understanding the demographics, mortality, hospital length of stay, and economic burden associated with ...
Background: Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP) is a rare and life-threatening condition characterized by microangiopathic hemolytic anemia, thrombocytopenia, and organ dysfunction. Understanding the demographics, mortality, hospital length of stay, and economic burden associated with ...