& Eser, M. RECRUIT-TandAbs: harnessing the immune system to kill cancer cells. Future Oncol. 8, 687–695 (2012). Article CAS PubMed Google Scholar Runcie, K., Budman, D. R., John, V. & Seetharamu, N. Bi-specifi
M. Paradoxical roles of the immune system during cancer development. Nat. Rev. Cancer 6, 24–37 (2006). Article PubMed CAS Google Scholar DeNardo, D. G. et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 1, 54–...
Immunosurveillance of cancer is well known. It is believed that escape from the immunosurveillance system and failure of the immunocytes to mount an adequate immune response lead to cancer. These and other evidences led to the development of immune check
Since the discovery of immune checkpoint proteins, there has been a special interest in developing antibodies that block programmed cell death 1 receptor (PD-1) and programmed cell death receptor ligand 1 (PD-L1) for a subset of cancer patients. PD-1 signaling negatively regulates T cell-mediat...
cancer development has led to the development of novel immunotherapies. Several immunotherapeutic strategies have been studied both preclinically and clinically and already have been shown to enhance the efficacy of conventional treatment modalities. Therefore, therapies targeting the immune system may ...
Cancer Immune System Evasion with Progesterone-Induced Blocking Factor In part one of this series, we discussed strategies to eradicate cancer stem cells using Doxycycline and high dose Vitamin C. Unfortunately, a few cancer stem cells, however small in number, will always remain behind at the ...
Upregulated lung cancer 10 VEGFR-2: Vascular endothelial growth factor receptor-2 VISTA: V-domain Ig suppressor of T cell activation WT-1: Wilms tumor gene-1 References Google Scholar PubMed CentralGoogle Scholar Dotan E, Cohen SJ, Starodub AN, et al. Phase I/II trial of labetuzumab gov...
Aging of the immune system, also referred to as immunosenescence, describes the age-related changes in immune function that lead to increased susceptibility of older people to infectious diseases, autoimmunity, and cancer. The capacity of the immune system to mount an adequate response decreases with...
N Engl J Med. 2000;343:1826–32. https://doi.org/10.1056/NEJM200012213432501. Article CAS PubMed Google Scholar Chen JH, Zhai ET, Yuan YJ, et al. Systemic immune-inflammation index for predicting prognosis of colorectal cancer. World J Gastroenterol. 2017;23:6261–72. https://doi.org/...
P. Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell 161, 205–214 (2015). CAS PubMed PubMed Central Google Scholar Palucka, A. K. & Coussens, L. M. The basis of oncoimmunology. Cell 164, 1233–1247 (2016). CAS PubMed PubMed ...