Nitric oxide and reduced nicotinamide adenine dinucleotide phosphate oxidase-dependent reactive oxygen species generation (due to the function of Respiratory Burst Oxidase Homolog proteins D and F) are also involved downstream from the Ca2+ signal in the Pep immune defense signal transduction cascade, ...
Recent studies identified two MAPK kinase kinases that are directly activated by RLCKs, and filled in a gap in immune signal transduction between PRR activation and the MAPK cascades.Access through your organization Check access to the full text by signing in through your organization. Access ...
cGAS can detect DNA and initiate a signaling cascade through the cGAS-cGAMP-STING-TBK1-IRF3 axis, ultimately triggering the transcription of type I IFNs178(Fig.3). In addition, STING can activate the MAPK and NF-κB pathways, although the mechanisms behind this activation remain to be clarifie...
Direct protein–protein interactions and signal blockade are other mechanisms that downregulate MAVS-mediated RLR signaling. Recent studies have shown that lactate, the end product of anaerobic glycolysis, acts as a negative regulator of RLR signal transduction by interacting with the TM domain of MAVS...
Babenco, Thyroxine signal transduction in liver cells involves phospholipase C and phospholipase D activation: genomic independent action of thyroid hormone, ... NS Kavok,OA Krasilnikova,NA Babenko - 《Bmc Cell Biology》 被引量: 93发表: 2001年 Insulin-induced phospholipase D1 and phospholipase...
2. Signal transduction cascades leading to necrotic cell death Death receptors belong to the TNF receptor superfamily. When they bind their extracellular ligands they aggregate and initiate a signalling pathway that results either in cell survival or in death [27]. Depending on the cellular context,...
(due to the function of Respiratory Burst Oxidase Homolog proteins D and F) are also involved downstream from the Ca2+ signal in the Pep immune defense signal transduction cascade, as is the case with BRASSINOSTEROID-INSENSlllVEl Associated Kinasel and CPK5, CPK6, and CPKll. These steps of...
1999. Human cytomegalovirus inhibits IFN-alpha-stimulated antiviral and immunoregulatory responses by blocking multiple levels of IFN-alpha signal transduction. Journal of Immunology, 162: 6107–6113. CAS ISI Google Scholar Milne, R.S.B., Mattick, C., Nicholson, L., Devaraj, P., Alcami, A....
inhibiting glutamine metabolism of macrophages has shown the ability to convert M2 macrophages into M1 macrophages.207The serine synthesis of macrophages has been reported to be upregulated in the TME through a protein kinase RNA-like ER kinase-signaling cascade, enhancing mitochondrial function and M2...
Thus, inhibition of antitumor immunity involves a cascade of Stat-3 activation propagating from tumor to dendritic cells. We propose that tumor Stat-3 activity can mediate immune evasion by blocking both the production and sensing of inflammatory signals by multiple components of the immune system. ...