检查点阻断(checkpoint blockade)是一种利用免疫反应来治疗癌症的强大新策略。溶瘤病毒疗法则是利用病毒来消灭肿瘤的一种干预疗法。来自Ludwig癌症研究中心的一项研究表明联合两者将有可能大大提高临床疗效。 发表在3月5日《科学转化医学》(Science Translational Medicine)杂志上的这项研究对联合治疗进行了评估。研究人员首...
Immune Checkpoint Blockade: InestimAble Advances-免疫检查点阻断:前景不可估量 在过去的十年里,随着调节T细胞反应研究的不断突破,为免疫检测点阻断单克隆抗体(mAbs)的发展提供理论基础,不断攻克癌症治疗的难题。尽管还存在疗效差异(10%到90%)...
正在加载 Neoadjuvant Immune Checkpoint Blockade Has Antitumor Activity Cancer Discov. Pub Date : 2018-12-01DOI : 10.1158/2159-8290.cd-rw2018-178 American Association for Cancer Research Neoadjuvant immunotherapy induces a stronger immune response than adjuvant immunotherapy. 查看原文 公开下载 中文翻译 ...
Immune checkpoint blockade: a common denominator approach to cancer therapy. The immune system recognizes and is poised to eliminate cancer but is held in check by inhibitory receptors and ligands. These immune checkpoint pathways, which normally maintain self-tolerance and limit collateral tissue ...
Immune Checkpoint Blockade: T Cell Responses There is great interest in identifying downstream T cell responses following immune checkpoint blockade to direct more effective treatments and better-informed therapeutic decisions. R&D Systems and Tocris offer a wide selection of reagents, kits, and assays ...
a几年没见你了 Several years have not seen you[translate] aelapsed SOAK 流逝浸泡[translate] afor the blockade of several other immune checkpoint molecules from the CD 28:B7 family 为几个其他免疫检查站分子封锁从CD 28 :B7家庭[translate]
近年来以免疫检查点阻断(ICB, immune checkpoint blockade)为代表的肿瘤免疫治疗在部分实体肿瘤病种如黑色素瘤、乳腺癌、肺癌等取得重要突破[1],然而包括KEYNOTE-059、ATTRACTION-2 在内的多个临床研究报道PD-1 抗体在胃癌患者的后线治疗客观应答率仅约12% [2, 3]。胃癌
Herein, we briefly review the history of immunotherapy and checkpoint blockade, highlighting important clinical failures. We discuss the critical aspects — beyond T cell co-receptors — of immune processes within the tumour microenvironment (TME) that may serve as avenues along which new therapeutic ...
Immune checkpoint blockade_中医中药_医药卫生_专业资料 暂无评价|0人阅读|0次下载|举报文档Immune checkpoint blockade_中医中药_医药卫生_专业资料。文档贡献者 噬菌体4号 贡献于2016-01-05 相关文档推荐 暂无相关推荐文档 ©2016 Baidu 使用百度前必读 | 文库协议 | 网站地图 ...