DENDRITIC cellsT cellsLYMPH nodesDendritic cells (DCs) patrol the organism at an immature stage to detect the presence of pathogens. Once activated, these mature DCs reach the lymph nodes to activate antigen-specific T lymphocytes and thus initiate an adaptative immune response to control the ...
Background: Dendritic cells (DCs) form a key link between innate and adaptive immune responses. The aim of this study is to analyze presence and distribution of immature (im) and mature (m) DCs in gingival tissue samples obtained from patients diagnosed with aggressive periodontitis (AgP), chro...
DCs (dendritic cells) function as sentinels of the immune system. They traffic from the blood to the tissues where, while immature, they capture antigens. They then leave the tissues and move to the draining lymphoid organs where, converted into mature DC, they prime naive T cells. This sug...
Purpose: The purpose of this study is to evaluate migration of technetium-99m hexamethylpropylene amine oxime (-HMPAO) labeled immature and mature dendritic cells (DC) in the mouse. Methods: DC were collected from bone marrow (BM) of tibiae and femurs of mice. Immature and mature DC from ...
Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator...
Susceptibility of Immature and Mature Langerhans Cell-Type Dendritic Cells to Infection and Immunomodulation by Human Cytomegalovirus Human cytomegalovirus (CMV) infection initiates in mucosal epithelia and disseminates via leukocytes throughout the body. Langerhans cells (LCs), the immat... Laura,Hertel,...
both if we considered all the animals or only those that have correctly consolidated the spatial information. Furthermore, when we analyzed the expression of Zif268 in BrdU-IR cells, the results demonstrated that mature adult-born neurons were activated by recent reconsolidation and that their activ...
Until now, studies utilizing mRNA electroporation as a tool for the delivery of tumor antigens to human monocyte-derived dendritic cells (DC) have focused on DC electroporated in an immature state. Immature DC are considered to be specialized in antigen capture and processing, whereas mature DC...
The MIP3α fusion component of this vaccine construct has two functions: (1) to target the vaccine antigen to the C–C Motif Chemokine Receptor 6 (CCR6) protein present on the surface of the immature dendritic cells (iDC) that initiate the adaptive immune response17,18and (2) to attract...
In the mutants, however, there were many PSA-NCAM positive cells in the granule cell layer. Moreo- ver, the amount of calbindin, a marker for mature neu- rons in the DG, -positive cells was dramatically reduced (Figure 3B and 3C). Thus, in the mutants, the number of immature neurons...