Transcriptionally mature and immature β-cells co-exist within the adult islet. How such diversity contributes to insulin release remains poorly understood. Here we show that differences in β-cell maturity, defined using PDX1 and MAFA expression, are required for proper islet operation. Functional ...
We studied the effects of polymorphonuclear neutrophils (PMN) and immature myeloid cells on the granulocyte colony-stimulating factor (G-CSF) level in vitro to better understand the regulatory mechanisms of neutropoiesis. Intact normal PMN decreased the G-CSF level after incubation with recombinant hum...
Precise molecular characterization of circulating polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) is hampered by their mixed composition of mature and immature cells and lack of specific markers. Here, we focus on mature CD66b+CD10+CD16+CD11b+ PMN-MDSCs (mPMN-MDSCs) from either...
The inactivation of metaphase-promoting factor (MPF), leading to reactivation of the oocyte cell cycle after fertilization, is one of the most important results of oocyte activation in the case of intracytoplasmic injection of mature or immature sperm cells. Oocyte activation is a cell signalling ev...
DCs (dendritic cells) function as sentinels of the immune system. They traffic from the blood to the tissues where, while immature, they capture antigens. They then leave the tissues and move to the draining lymphoid organs where, converted into mature DC, they prime naive T cells. This sug...
Immature porcine Sertoli cells have been reported to be targets for the regulatory peptide somatostatin (SRIF), which inhibits the basal and FSH-induced pr... Goddard,I. - 《Biology of Reproduction》 被引量: 61发表: 2001年 Leptin expression in the testicular tissue of fertile and infertile me...
To clarify the expression of immature and mature retinal cell makers in retinoblastoma cells and to give insights into the cell origin of the retinoblastoma. Five samples from five eyes diagnosed with retinoblastomas were analysed by a standard immunohis
Mature CD10(+) and immature CD10(-) neutrophils present in G-CSF-treated donors display opposite effects on T cells (vol 129, pg 1343, 2017) Marini,O.,Costa,... - 《Blood the Journal of the American Society of Hematology》 被引量: 13发表: 2017年 Mature CD10(+) and immature CD10...
These neutrophils inhibit proliferation and interferon γ (IFNγ) production by T cells via a CD18-mediated contact-dependent arginase 1 release. By contrast, we found that immature CD66b+CD10− neutrophils, also present in GDs, display an immature morphology, promote T-cell survival, and ...
The effects of PPAR agonists were examined on eosinophil chemokinesis, eotaxin-induced migration of eosinophils, and migration of IL-5R??+ CD34+ cells. Expressions of CCR3, phospho-p38, phospho-ERK, and calcium release were also measured in eosinophils after rosiglitazone treatment. Low ...