Myeloid derived suppressor cells (MDSC) are a heterogeneous group of myelomonocytic cells that have been implicated in tumor-induced immunosuppression in both mice and humans. Importantly, in murine models, inhibition of MDSC migration or activity has been shown to decrease tumor growth, inhibit ...
A population of suppressive CD11b+Gr-1+ cells has in fact been designated as myeloid-derived suppressor cells (MDSCs). MDSCs are a unique category of the myeloid lineage, and they induce the prevention of the development of cytotoxic T lymphocytes (CTLs) in vitro, and the induction of ...
Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity Myeloid-derived suppressor cells (MDSC) accumulate in most cancer patients and experimental animals with cancer. They accumulate in response to pro-inflamm... S Ostrand-Rosenberg - 《Cancer Immunology Immunotherapy》 被引...
In this study, we demonstrate that the bone marrow, blood, and secondary lymphoid organs of healthy aged mice possess increased numbers of immature myeloid cells that are phenotypically similar to myeloid-derived suppressor cells found in lymphoid organs of mice with progressive tumors and other ...
infected treatment naïve individuals have significantly higher myeloid-derived suppressor cell (MDSCs) levels, a considerable part of LDGs’ functionality compared to healthy controls41. Furthermore, CD66b, CD63, CD11b, and arginase 1 expression were increased on LDGs from treatment naïve ...
7,8,10 Accordingly, the presence of immunosuppressive LDNs, also known as granulocytic myeloid-derived suppressor cells (G-MDSCs), has been identified in the peripheral blood from patients with cancer,8,11, 12, 13 HIV-1 infections,14,15 sepsis,16 graft-versus-host disease,17 as well as ...
IMCImmature Myeloid Cell IMCInformation Multimedia Communication(various locations) IMCIndian Motorcycle Company(Delaware) IMCIrwin Mortgage Corporation(various locations) IMCInternal Mammary Chain(breast cancer) IMCInteractive Media Center IMCIndus Motor Company ...
Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties. J Leukoc Biol. 2011;89:311–7. Article CAS PubMed Google Scholar Guglietta S, Chiavelli A, Zagato E, Krieg C, Gandini S, Ravenda PS, et ...
Cytokine-induced killer (CIK) cells are ex vivo, expanded T cells with proven anticancer activity in vitro and in vivo. However, their functional properties with the exception of their cancer cell-killing activity are largely unclear. Here, we show that CIK T cells recognize dendritic cells (DC...
Leukemia www.nature.com/leu ARTICLE OPEN ACUTE MYELOID LEUKEMIA The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes Mette Louise Trempenau 1,2,3, Mikkel Bruhn Schuster1,2,3,11, Sachin Pundhir1,2,3,4,11, Mafalda Araujo ...