The rational combination of two catalysts to expedite the construction of chiral complex biologically and pharmacologically relevant chiral compounds has widely gained momentum over the past decade. In particular, enamine or iminium catalysis ensuing from the activation of aldehyde or keton...
iminiumenamineactivation活化enantioselectiveimidazolidinone IminiumandEnamineActivation: MethodsforEnantioselectiveOrganocatalysis Thesisby SeanPomeroyBrown InPartialFulfillmentoftheRequirements fortheDegreeof DoctorofPhilosophy CaliforniaInstituteofTechnology Pasadena,California 2005 (DefendedFebruary22,2005) ii ©2005 Sean...
The applications of enamine-iminium (EN-IM) catalysis in organocatalytic cascade reactions become a very useful strategy in organic synthesis. This review article aims to focus on an important overview about different strategies employed in the production of value added organic products. An effort has...
Catalysis: Merging Iminium and Enamine ActivationsConclusions Diels–Alder Reactions[3+2]-CycloadditionsCyclopropanationsEpoxidations[4+3]-Cycloadditions Friedel–Crafts AlkylationsMukaiyama–Michael ReactionsMichael Reactions of α,β-Unsaturated Ketones Cascade Addition–Cyclization ReactionsCascade Catalysis: ...
Chiral iminium ions—generated upon condensation of α,β-unsaturated aldehydes and amine catalysts—are used extensively by chemists to make chiral molecules in enantioenriched form. In contrast, their potential to absorb light and promote stereocontrolled photochemical processes remains unexplored. This is...
摘要: The mono-triflate salts of some chiral nonracemic 1,2-diamines react with α-ketoenones in a stoichiometric reaction to form products of the Nazarov cyclization in high enantiomeric ratios. The mechanism appears to involve rearrangement of an enamine−iminium ion....
2-halogen-substituted pyridinium-N-phenacylides and their cycloiminium and acyclic analogs: 1. Synthesis of the parent salts, their betaine-ylides, and oxa... This review deals with an important class of multifunctional reagents, namely, 2-halogen- N -phenacyl pyridinium salts 1 capable of formi...
‘On Water’ Iminium/EnamineCatalysis: Organocatalytic Enantioselective Cyclopropanation of α,β-UnsaturatedAldehydes[J] . Uxue Uria,Jose Vicario,Dolores Badía,Luisa Carrillo,Efraim Reyes,Amaia Pesquera.Synthesis . 2010 (04)URIA.U,,VICARIO.J.L,,BADIA.D,,CARRILLO.L, et,al.’’On Water’’ ...
Zhang, X,Zhang, S,Wang, W.Iminium-allenamine cascade catalysis:one-pot access to chiral 4H-chromenes by a highly enantioselective Michael-Michael sequence. Angewandte Chemie International Edition . 2010Zhang, X.-S., Zhang, S.-L. & Wang, W. Iminium-allenamine cascade catalysis: one-pot ...
Zhang, X,Zhang, S,Wang, W.Iminium-allenamine cascade catalysis:One-pot access to chiral 4H-chromenes by a highly enantioselective Michael-Michael sequence. Angewandte Chemie International Edition . 2010Iminium-allenamine cascade catalysis:One-pot access to chiral 4H-chromenes by a highly ...