Me3SiCl-Promoted Three-Component Coupling Reaction of a Functionalized Enamine, an Acetal, and an Alkyne: An Unprecedented Approach to the Synthesis of ... T Sasada,N Sakai,T Konakahara - 《Cheminform》 被引量: 0发表: 2009年 ChemInform Abstract: Me3SiCl‐NaI‐CH3CN as an Efficient and Pra...
of acetoacetic acid to form the corresponding enamine (II); (b) reaction of (II) with alpha-bromo-diethylcarbonate Br-C(CH3)H-OCOOC2H5 (III) to form the 1-(ethoxycarbonyloxy)ethyl ester (IV) and (c) acid hydrolysis to yield (I). In formulae R1 is 1-4C alkyl, opt. substd. ...
O + CH3NH2 H+ NHCH3 + H2O an imine (b) Now give a mechanism for a similar reaction that gives an enamine. O CH3NH2 H NHCH3 H2O una imina (b) Ahora proporcione un mecanismo para una reacción similar que forme una enamina. Literature An enamine is a tertiary amine with a ...
red gradually.After completion ( the reaction was monitored b、r 1I ) 。the 联lcti0n was quenched with dilute HC1 and ex. tracted with ether ( 3 ×20 mL) .皿le combined extract was washed with saturated brine ( 15 mL ) and dIied over anhy. drous Na2SO4 . A Rer evaporat...
of acetoacetic acid to form the corresponding enamine (II); (b) reaction of (II) with alpha-bromo-diethylcarbonate Br-C(CH3)H-OCOOC2H5 (III) to form the 1-(ethoxycarbonyloxy)ethyl ester (IV) and (c) acid hydrolysis to yield (I). In formulae R1 is 1-4C alkyl, opt. substd. ...
Di(tert-butylmethyl)ketazine (I) reacts with n-BuLi in a 1:1 molar ratio to give a monolithium salt (II). The reaction of II with tBu2SiF2 in n-hexane leads, even in a 1:1 molar ratio, to the formation of the isomeric five- and four-membered ring compounds 1 and 2. ...
where R = H, -CH3 or tert-butyl, so as to isomerise the double bond (a) to the position (b) to form the corresponding enamine; if R3 = H, hydrotropy tautomerism occurs at the CH2-N-Y-group to form the imine. The preparation of the catalyst is described. The reaction is preferab...
The reaction is preferably carried out in a solvent such as an ether, ketone or halide at 80 DEG to 120 DEG C for 1-15 hours using 1:2,000 to 1:10,000 mole catalyst per mole of derivative (I), followed by distillation off of the solvent. The products are obtained in high yield ...
The ML2(CH3OH)2 complexes have been obtained by the reaction of Cu(II), Ni(II) and Co(II) acetates with 2,2,5,5-tetramethyl-4-nitromethylidene-3-imidazolidine-1-oxyl (LH) in methanol and the CuL2 complex by the reaction of Cu(CH3COO)2路H2O with LH in ethanol. Investigation of...
of acetoacetic acid to form the corresponding enamine (II); (b) reaction of (II) with alpha-bromo-diethylcarbonate Br-C(CH3)H-OCOOC2H5 (III) to form the 1-(ethoxycarbonyloxy)ethyl ester (IV) and (c) acid hydrolysis to yield (I). In formulae R1 is 1-4C alkyl, opt. substd. ...