A new method for imatinib synthesis was described by using the C鈥揘 coupling reaction of 4-(4-methylpiperazine-1-methyl)benzamide with N-(5-bromo-2-tolyl)-4-(3-pyridyl)pyrimidin-2-amine to form imatinib. In this synthetic route, the high efficiency and high selectivity of nano-ZnO as ...
P308+P313 IF exposed or concerned: Get medical advice/ attention. Storage P405 Store locked up. Disposal P501 Dispose of contents/container to ... 2.3 Other hazards which do not result in classification none View all 5. Synthesis Route152459-95-5Total: 38 Synthesis Route 99...
571186-93-1Total: 1 Synthesis Route 152459-95-5 307 Suppliers 571186-93-1 12 Suppliers 5. Precursor and Product precursor: 152459-95-5 6. Computed Properties Molecular Weight:525.60154g/mol Molecular Formula:C29H31N7O3 Compound Is Canonicalized:True Exact Mass:2.4 XLogP3-AA:525.24883788...
Bioavailability of the agent is nearly 100% by the oralroute. The agent is highly protein bound and metabolized tothe N-desmethyl derivative by CYP3A4-mediated removalof the piperazinyl methyl group. The resulting metabolite issimilar to the parent in activity. Elimination occurs primarilyin the ...
It was previously reported that the presence or absence of TMPRSS2 determines the SARS-CoV-2 entry route either via membrane fusion or endocytosis, respectively10,14. E64d, a cathepsin L inhibitor, significantly inhibits endosomal SARS-CoV-2 infection mainly in the absence of TMPRSS2 while camos...
The aim of this study was to develop mesoporous bioglass (MBG) with improved bioactivity and controllable drug delivery rate. By using pluronic 123 (P123) as a template, a facile sol-gel route was employed for the synthesis of MBG nanoparticles (NPs). The composition of the prepared sample ...
Bioavailability of the agent is nearly 100% by the oralroute. The agent is highly protein bound and metabolized tothe N-desmethyl derivative by CYP3A4-mediated removalof the piperazinyl methyl group. The resulting metabolite issimilar to the parent in activity. Elimination occurs primarilyin the ...
The method for preparing N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine has the advantages of easily available raw materials, simple operation, high total yield of the above reaction, and is a synthesis route suitable for industrially producing N-(5-amino-2-methylphenyl)-4-(3-...
Bioavailability of the agent is nearly 100% by the oralroute. The agent is highly protein bound and metabolized tothe N-desmethyl derivative by CYP3A4-mediated removalof the piperazinyl methyl group. The resulting metabolite issimilar to the parent in activity. Elimination occurs primarilyin the ...
This method is cheap and available starting material, process route segment, easy to operate the reaction process engineering, high yield, environmentally friendly and suitable for industrial mass production.石茂健周金辉徐志强管华上官国强