Mode of action Imatinib binds close to the ATP-binding site of BCR-ABL and locks it in a closed inactive conformation which excludes ATP. This shuts down its sustained signaling, thus blocking leukemic cell growth. References [1] elisabeth buchdunger, catherine l. cioffi, norman law, david ...
Beside its direct effects to treat cancers as aTKI, imatinib can also be used as sensitizing agent for other chemotherapeutics. Some of the mechanisms have been highly related with certainABC transportersas well as other mode of actions. These results may shed the light for treatment ofMDRcancers...
Ormiston ML, Deng Y, Rundle N, Bendjelloul F, Tsoporis JN, Parker TG, Stewart DJ, Courtman DW (2013) A lymphocyte- dependent mode of action for imatinib mesylate in experimental pulmonary hypertension. Am J Pathol 182(5):1541-1551
Given the fact that lenti-Spike is replication-incompetent, imatinib mode of action does not require viral replication. Further study revealed that imatinib inhibited membrane fusion mediated by Spike and hACE2 (Fig. 3c, d). In the absence of TMPRSS2, imatinib was as potent as the cathepsin...
Ormiston ML, Deng Y, Rundle N, Bendjelloul F, Tsoporis JN, Parker TG, Stewart DJ, Courtman DW (2013) A lymphocyte-dependent mode of action for imatinib mesylate in experimental pulmonary hypertension. Am J Pathol 182(5):1541–1551 Article CAS PubMed Google Scholar Sun C-K, Lee F-Y...
The Acta Pharmacologica Sinica www.chinaphar.com Wu LX et al npg 403 reaction was stopped by addition of 10 µL Kinase-Glo reagent, and the plate was read after a 10-min incubation time at RT on the Thermo Scientific Varioskan Flash in luminescence mode. Western blotting analysis of Bcr...
aselect safe mode[translate] a鼓励大家 Encourages everybody[translate] a教室里有棕色的桌子、黄色的椅子、还有绿色的黑板 In the classroom has the brown table, the yellow chair, also has the green blackboard[translate] athe entire city lay in ruins 整个城市位置在废墟[translate] ...
Mode of actionImatinib binds close to the ATP-binding site of BCR-ABL and locks it in a closed inactive conformation which excludes ATP. This shuts down its sustained signaling, thus blocking leukemic cell growth. references[1] elisabeth buchdunger, catherine l. cioffi, norman law, david stove...
Our data link for the first time the process of autophagy with the mode of action of imatinib. Induction of autophagy might represent an additional mechanism of imatinib to induce growth arrest, promote apoptosis in cancer cells and eventually even promote tumour regression....
Imatinib (IM) selectively inhibits the activity of some tyrosine kinases, including BCR-ABL1 and c-KIT. Mainly because of this mode of action, it has been registered as the first line treatment option for patients with chronic myeloid leukemia (CML) in the chronic, accelerated and blast ...