For example, failure to respond to the currently available ICI may require blocking of other inhibitory pathways, either receptor-mediated or involving soluble factors present in the TME. A therapeutic failure of CAR-T cells may reflect the loss of the tumor antigen targeted by CAR or the ...
Innate lymphoid cells (ILCs) are crucial for the immune surveillance at mucosal sites. ILCs coordinate early eradication of pathogens and contribute to tissue healing and remodeling, features that are dysfunctional in patients with cystic fibrosis (CF).