IL4 gene / cDNA is a protein-coding gene which located on 5q31.1. The IL4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.133 organisms have orthologs with human gene IL4. All IL-4 genes IL-4 基因功能 The protein encoded by this gene is a pleiotropic ...
Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] [中文简述(自动翻译):] 由该基因编码的蛋白质是由激活的T细胞产生的多效细胞因子。这种细胞因子是白介素4受体的配体。白细胞介素4受体还结合IL13,这可能有助于这种细胞...
IL4 gene polymorphisms in Iranian patients with autoimmune hepatitis. Expert Rev Gas- troenterol Hepatol 2016;10(5):659--63.Yousefi A, Mahmoudi E, Zare Bidoki A, et al.IL4 gene polymorphisms in Iranian patients with autoimmune hepatitis[J].Expert Rev Gastroenterol Hepatol, 2016, 10 (5) ...
S.Y. (2022). Transcription Factor EGR1 Regulates the Expression of the Clock Gene PER2 under IL-4 Stimulation in Human Keratinocytes. Journal of Investigative Dermatology, [online] 142(10), pp.2677-2686.e9. doi:https://doi.org/10.1016/j.jid.2022.03.021. ...
(TLR) ligand-activated transcriptional programs mutually antagonize each other, and no remarkable convergence has been identified between them. In contrast, here, we show that IL-4-polarized macrophages established a hyperinflammatory gene expression program upon lipopolysaccharide (LPS) exposure. This ...
Acute expression of the IL4 gene by differentiated TH2 cells is regulated by many positive and negative inducible transcription factors, such as nuclear factor of activated T cells (NFAT) proteins, AP1, nuclear factor-κB, interferon regulatory factor 1 (IRF1) and other factors that bind the pr...
il -4基因的骨髓间充质干细胞对豚鼠免疫性内耳病基因治疗的研究 gene therapy of inner ear injection with bone -marrow mesenchymal stem cells decorated with interleukin-4 gene on immune-mediated inner ear disease in guinea pigs 下载文档 收藏 打印 转格式 il...
GeneID 16189 Source E.coli-derivedmouseIL-1alpha protein,His21-Ser140,with an N-terminal Met. Molecular Weight Approximately13.5kDa. AA Sequence MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S ...
Because it is involved in upregulating IgE, IL4 is thought to play a key role in allergic disease. Thus far, researchers have identified two polymorphisms in the IL4 gene, one of which seems to affect IgE levels and bronchial hyperresponsiveness. Until now, however, a complete screen...
4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a ...