Studies have suggested that IL-23/STAT3 and IL-12/STAT4 signaling pathways associate with aplastic anemia (AA) occurrence. Polymorphisms in pathway-related genes may contribute to AA risk. In the current study, we investigated the association between polymorphisms in genes of IL23R , STAT3 , ...
subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner....
subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner....
IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul ...
对非创伤性股骨头坏死分子预警及分子水平防治具有重大价值。技术要求 1.检测与非创伤性股骨头坏死风险性有关IL23R基因的单核苷酸多态性的物质，其特征在于：所述物质在诊断或辅助诊断非创伤性股骨头坏死中的应用，或在制备诊断或辅助诊断非创伤性股骨头坏死风险性的产品中的应用；
Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese. The cases and controls were genotyped for 115 single nucleotide polymorphisms (SNPs) tagging IL23R, ERAP1, STAT3, JAK2, TNFRSF1A and TRADD, as well as... PM Visscher,MA Brown,H Xu - 《Annals of the Rheumatic Di...
Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese. OBJECTIVES: Recent association studies by the Australo-Anglo-American Spondyloarthritis Consortium (TASC) in Caucasian European populations from Australia,... PM Visscher,MA Brown,H Xu - 《Annals of the Rheumatic Diseases ...
We show that all three of these IL23R伪 variants cause a reduction in IL23 receptor activation-mediated phosphorylation of the signal-transducing activator of transcription 3 (STAT3) and phosphorylation of signal transducing activator of transcription 4 (STAT4). The reduction in signaling is due to...
IL23R R381Q gene variant reduces IL-23-induced IL-17A production and STAT3 phosphorylation.Paola Di MeglioAntonella Di CesareUte LaggnerChungChing ChuLuca NapolitanoFederica VillanovaIsabella TosiFrancesca CaponRichard C. TrembathKetty Peris
JAK2, TYK2 and STAT3 were required for IL23-induced mechanisms. IL23 and IL12 induced antimicrobial pathways to similar levels in human macrophages. Relative to IL23R-R381, transfected IL23R-Q381 or MDMs from IL23R-Q381 carriers demonstrated reduced bacterial uptake and clearance. Conclusion We ...