A protease-activated IL-2 fusion protein was designed to attempt to block wild-type IL-2 (WT-IL2) with IL2Rα35. However, this fusion does not contain any modality to extend half-life, such as Fc. Furthermore, this fusion uses WT-IL2 and thus has higher affinity for Tregs when cleave...
The IL2R alpha (CD25) is responsible for activating the IL2 signaling complex and regulates the signal transduction [14, 15]. The IL2-R alpha subunit forms the largest of the three IL-2/IL2-R interfaces. Association of α chain with the β and γ heterodimer creates a receptor with a ...
One week after vaccination boost, splenocytes and tumor cells were isolated and the lymphocytes expressing CD4 and CD25 were classified as Treg cells. Among the splenocytes of tumor- bearing mice, those administered both pcDNA3-CRT/E7 and IL2 DNA plasmids had the highest ratio of CD8+ T...
Gene Aliases: RP11-536K7.1, CD25, IDDM10, IL2R, TCGFR Product Size: 5 x 5 µg Protein Form: Truncated, Recombinant Purification: PAGE Tag Position: C-Terminal Protein Family: CD Proteins, Cytokines & Receptors Endotoxin Level: < 1 EU/µg Molecular Weight: 23.3 kDa ...