NLRP3/caspase-1-independent IL-1beta production mediates diesel exhaust particle-induced pulmonary inflammation. J. Immunol. 187(6), 3331-3337 (2011).Provoost S, Maes T, Pauwels NS, Vanden Berghe T, Vandenabeele P, Lambrecht BN, et al. NLRP3/caspase-1-independent IL-1beta production ...
The NLRP3 inflammasome was activated after ICH and was located in the microglial cell of the mouse brain, which exhibits a time-dependent manner. However, the number of NLRP3/Iba-1 dual-labeled cells in the C3−/− group is less than that in the WT group in each time course, ...
A mutation in the inflammasome protein NLRP3 (NACHT, LRR and PYD domains-containing protein 3) causes excess production of IL-1β, resulting in an ... SY Woo - 《International Immunology》 被引量: 258发表: 2012年 Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1...
THE ATTENUATION OF IL‐1BETA RESPONSE IN MAC‐LD IS DUE TO BOTH DECREASES OF NLRP3 INFLAMMASOME AND TLR2 ACTIVATIONinflammasomeactivation pathwaytranscription pathwaymacrophageMycobacterium avium complexdoi:10.1111/resp.13207_30NoneJohn Wiley & Sons, LtdRespirology...
The inflammasome is a multi-protein complex made of a PRR, such as Nod-like receptor family, pyrin domain containing 3(NLRP3), an adaptor, such as apoptosis-associated spec-like protein containing a CARD (ASC), and pro-caspase-1 (1-3,5). Assembly of the inflammasome enables cleavage of...
The inflammasome is a multi-protein complex made of a PRR, such as Nod-like receptor family, pyrin domain containing 3(NLRP3), an adaptor, such as apoptosis-associated spec-like protein containing a CARD (ASC), and pro-caspase-1 (1-3,5). Assembly of the inflammasome enables cleavage of...
a抑制后能够减少高糖所致肾小管上皮细胞的损伤,其机制可能与NLRP3、ASC、及IL-1β的活化密切相关。 After the suppression can reduce the high sugar result tubulus renalis epithelial cell the damage, its mechanism possible and NLRP3, ASC, and IL-1β activation close correlation.[translate]...
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Authors - Yiqing Yan View Article zebrafish IF Cell Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System. Authors - Yunlu Zhu View Article WB Trends Biot...
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Authors - Xiaqiong Wang View Article human,mouse WB Nat Cell Biol Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity. Authors - Yi Huang View Article hu...
7-Database links 8-Target type 9-Primary research area 10-Other research areas 11-Molecular weight The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. IL1B lacks any ...