The NLRP3 inflammasome was activated after ICH and was located in the microglial cell of the mouse brain, which exhibits a time-dependent manner. However, the number of NLRP3/Iba-1 dual-labeled cells in the C3−/− group is less than that in the WT group in each time course, ...
A mutation in the inflammasome protein NLRP3 (NACHT, LRR and PYD domains-containing protein 3) causes excess production of IL-1β, resulting in an ... SY Woo - 《International Immunology》 被引量: 258发表: 2012年 Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1...
human,mouseWB Nat Cell Biol Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity. human,mouseWB Nat Commun CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. ...
THE ATTENUATION OF IL‐1BETA RESPONSE IN MAC‐LD IS DUE TO BOTH DECREASES OF NLRP3 INFLAMMASOME AND TLR2 ACTIVATIONinflammasomeactivation pathwaytranscription pathwaymacrophageMycobacterium avium complexdoi:10.1111/resp.13207_30NoneJohn Wiley & Sons, LtdRespirology...
Conclusions These findings suggest that oxLDL-induced NLRP3 inflammasome activation mainly depends on CD36 involved in the progression of atherosclerosis by promoting oxLDL-mediated inflammation and foam cell formation. 展开 关键词: Vascular disease oxLDL IL-1β NLRP3 inflammasome CD36 Foam cells ...
The inflammasome is a multi-protein complex made of a PRR, such as Nod-like receptor family, pyrin domain containing 3(NLRP3), an adaptor, such as apoptosis-associated spec-like protein containing a CARD (ASC), and pro-caspase-1 (1-3,5). Assembly of the inflammasome enables cleavage of...
The inflammasome is a multi-protein complex made of a PRR, such as Nod-like receptor family, pyrin domain containing 3(NLRP3), an adaptor, such as apoptosis-associated spec-like protein containing a CARD (ASC), and pro-caspase-1 (1-3,5). Assembly of the inflammasome enables cleavage of...
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Authors - Yiqing Yan View Article zebrafish IF Cell Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System. Authors - Yunlu Zhu View Article WB Trends Biot...
a抑制后能够减少高糖所致肾小管上皮细胞的损伤,其机制可能与NLRP3、ASC、及IL-1β的活化密切相关。 After the suppression can reduce the high sugar result tubulus renalis epithelial cell the damage, its mechanism possible and NLRP3, ASC, and IL-1β activation close correlation.[translate]...
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Authors - Xiaqiong Wang View Article human,mouse WB Nat Cell Biol Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity. Authors - Yi Huang View Article hu...