7 | DR-18 treatment enhances lymphocyte effector function. 7. DR-18扩增瘤内干细胞样T细胞 近年的文献显示,持久的免疫治疗反应需要表达TCF1和PD-1的干细胞样(stem-like)CD8+ T细胞前体细胞群,这些干细胞样前体细胞分化为终末效应细胞,将失去TCF1的表达,获得TIM3,具有更大的效应功能,但其自我更新能力有限[...
Interleukin 18 binding protein (IL-18 BP) is a secreted glycoprotein, which may function as a natural anti-inflammatory and immunosuppressive molecule neutralizing the effects of high IL18 levels during inflammation. It can prevent IL18 receptor binding and inhibits the production of IFN-gamma ...
7 DR-18 treatment enhances lymphocyte effector function. Related to Fig. 3. Wild-type mice were engrafted s.c. with 0.5 × 106 MC38 or YUMMER1.7 cells. From day 7 after engraftment mice were treated twice weekly i.p. with PBS, IL-18, or DR-18. Tumours were harvested and analysed ...
参考文献以下引用的文献纳入本说明书作为参考。 1Anderson,D.M.,Maraskovsky,E.,Billingsley,W.L.,Dougall,W.C.,Tometsko,M.E.,Roux,E.R.,Teepe,M.C.,DuBose,R..F,Cosman,D.,Galibert,L.(1997)“A.homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell funct...
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andIL-18/IL-18BPimbalancemayparticipateinittoo.DynamicmonitoringofIL-18andIL-18BPinperipheralbloodcanbeusedasareflectionoftheimmunefunctionofstatechangesindexinHIV-1infectedpatients,regulatethebalancebetweenIL-18andIL-18BPmayprovideanewapproachforthetreatmentofAIDS.ToconductHighlyactiveantiretroviraltherapy(HAART)...
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
IL-18BP is presumed to play a vital regulatory function in IL-18-mediated immune responses, although its precise role in immunomodulation in various diseases is not well understood. In the present study, we have generated and characterized a mouse monoclonal antibody (2A6H11), specific for rat...
(P<0.01).CONCLUSION Serum levels of IL-18 and IL-18BP can reflectthe immune function of patients with primary liver cancer,withvarious benign liver tumors or with LC and can also be indicativeof the clinic stage of primary liver cancer.It can be used to assistin making a diagnosis and ...
Interleukin-18 (IL-18) serves a dual function in the immune system, acting as a "double-edged sword" cytokine. Depending on the microenvironment and timing, IL-18 can either drive harmful inflammation or restore immune homeostasis. Pathologies characterized by elevated IL-18, recently proposed to...