Lack of IL-17RD did not result in differences in CIA severity, but preliminary data suggest changes in the incidence between IL-17RD knockout mice compared to wild type littermates. Conclusions An inflammatory environment causes synovial fibroblasts to downregulate IL17RD expression. Lack of IL...
Multiple pathways converge to result in the overexpression of T17 cells in the absence of either vitamin D or the vitamin D receptor (VDR). CD4 T cells from VDR knockout (KO) mice have a more activated phenotype than their wild-type (WT) counterparts and readily develop into T17 cells ...
The interleukin-17 (IL-17) cytokine family is crucial to the progression of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). It has been shown in a neuroectoderm-specific knockout study that astrocyte-restricted ablation of Act1, a key and common tran...